This report presents a biostatistical analysis of the association between depression and obesity, based on a longitudinal study conducted at Australian Catholic University (ACU). The study involved 500 participants, including individuals with depression, obesity, and both conditions, and utilized statistical methods such as variance analysis, regression, and correlation to investigate the relationship between these two health issues. The results, presented in tables, explore the demographic characteristics and the statistical tools used, including tests for equality of variances and means. While the study found that obesity does not directly cause depression, it highlights the complex interplay of psychosocial, eating habits, diet, and socio-demographic factors in these conditions. The report concludes with recommendations for further research and emphasizes the importance of regular monitoring of weight and mental health, along with the need for psychological counseling and dietary management for affected individuals.