This case study analyzes Mr. Papas, a 54-year-old Greek man presenting with central chest pain, nausea, diaphoresis, and radiating pain, indicative of an acute myocardial infarction (AMI). The analysis explores risk factors such as smoking and a sedentary lifestyle, and delves into the pathophysiology, specifically STEMI, the formation of thrombus, and the role of atherosclerosis. It examines the patient's pallor and clamminess as signs of the condition and discusses homeostasis mechanisms, including referred pain. Furthermore, the assignment outlines essential nursing treatments, including pain management with aspirin, administration of clopidogrel, and the importance of percutaneous coronary intervention (PCI) and reperfusion therapy. The study emphasizes the critical role of nurses in managing AMI patients, focusing on health promotion and patient education, including smoking cessation, dietary changes, and exercise to improve the patient’s long-term health outcomes.