This report delves into the critical aspects of clinical decision-making in nursing, emphasizing its collaborative and integrative nature. It explores the process, highlighting the importance of clinical reasoning, which involves gathering patient cues and applying knowledge to formulate diagnoses and care plans. The report discusses strengths such as nurses' knowledge and interdepartmental unity, alongside weaknesses like knowledge gaps and departmental disunity. A case study of a 90-year-old patient with multiple conditions is presented to illustrate the clinical reasoning cycle, from initial assessment to evaluation. The report underscores the significance of reflective practice, open-mindedness, and continuous learning, advocating for incorporating the clinical reasoning cycle into nursing curricula. It concludes by stressing the value of patient-centered care, collaboration, and thorough documentation, with recommendations for preventive campaigns and enhanced nursing education. The report provides a comprehensive understanding of clinical decision-making in nursing, promoting quality patient care through effective strategies and practices.