Annotated Bibliography on Acute Lymphocytic Leukemia (ALL) - Research

This annotated bibliography focuses on Acute Lymphocytic Leukemia (ALL), presenting a selection of key research articles. It includes studies investigating genetic polymorphisms in folate pathways, the efficacy and toxicity of CAR T-cell therapy, the identification of multifactorial causation and genetic susceptibility, the role of specific genes (CDK2, CCND1, and CMYC), and the impact of collaborative studies on understanding and treating the disease. Each entry provides a concise summary of the study's objectives, methods, key findings, and the authors' rationale for inclusion, offering a comprehensive overview of current research in ALL.

Running head: ACUTE LYMPHOCYTIC LEUKEMIA 1
Annotated bibliography on Acute Lymphocytic Leukemia (ALL)
Frederick Wilson
Columbia Southern University

ACUTE LYMPHOCYTIC LEUKEMIA 2
Akin, D. F., Oner, D. A., Sipahi, K., Mumcuoglu, M., Kurekci, E., Ezer, U., & Akar, N. (2017).
Screening of polymorphisms in the folate pathway in Turkish pediatric Acute
Lymphoblastic Leukemia patients. Egyptian Journal of Medical Human Genetics, 18(4),
p349-353. 5p.
The authors investigated polymorphisms of folate related genes that increase the
susceptibility to childhood ALL. Genotyping, RFLP AND RT-PCT screened 5
polymorphisms. The article was chosen as it showed an association between TYMS
1494del6 and ALL and demonstrated lack of association with DHFR, MTHFR and CBS
genes.
Davila, M. L., Riviere, I., Wang, X., Bartido, S., Park, J., Curran, K., ... & Qu, J. (2014).
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute
lymphoblastic leukemia. Science translational medicine, 6(224), 224ra25-224ra25.
The authors aimed to assess the effectiveness of autologous T cells that expressed 19-28z
chimeric antigen receptor on ALL. It identified the diagnostic criteria for severe cytokine
release syndrome and found serum C-reactive proteins to be reliable indicators. This
article was chosen as it provided strong evidence for conduction of T-cell therapy.
Inaba, H., Greaves, M., & Mullighan, C. G. (2013). Acute lymphoblastic leukaemia. The
Lancet, 381(9881), 1943-1955.
This article helped in the identification of the multifactorial causation, genetic
susceptibility and exposure rates that increase the likelihood of a person becoming
affected with ALL. The study was chosen as it identified novel structural mutations and
genetic changes through genome wide profiling and also helped in defining new disease
subtypes and treatment response.

ACUTE LYMPHOCYTIC LEUKEMIA 3
Jayaraman, A., & Jamil, K. (2012). Clusters of CDK2, CCND1, and CMYC genes involved in
cancers: Acute Lymphocytic Leukemia (ALL) as a model. Biology and Medicine, 4(1),
37.
The study analysed the cell cycles and role of the CCND1, CKD2 and C-MYC genes on
ALL in children. A thorough search of literature databases, sequencing of DNA and
phylogenetic tree construction was done. The article was chosen as it helped in
determining loss of functions in the genes during the course of evolution.
Pui, C. H., Yang, J. J., Hunger, S. P., Pieters, R., Schrappe, M., Biondi, A., ... & Escherich, G.
(2015). Childhood acute lymphoblastic leukemia: progress through collaboration. Journal
of Clinical Oncology, 33(27), 2938-2948.
The authors evaluated the impact of collaborative studies that would help in providing a
clear understanding of the advances in the physiology and treatment of the disease in
children and adolescents. This article adds to the chosen topic since it provided
information on ALL heterogeneity that could be used to improve personalized treatment
and quality of life.

ACUTE LYMPHOCYTIC LEUKEMIA 4
References
Akin, D. F., Oner, D. A., Sipahi, K., Mumcuoglu, M., Kurekci, E., Ezer, U., & Akar, N. (2017).
Screening of polymorphisms in the folate pathway in Turkish pediatric Acute
Lymphoblastic Leukemia patients. Egyptian Journal of Medical Human Genetics, 18(4),
p349-353. 5p.
Davila, M. L., Riviere, I., Wang, X., Bartido, S., Park, J., Curran, K., ... & Qu, J. (2014).
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute
lymphoblastic leukemia. Science translational medicine, 6(224), 224ra25-224ra25.
Inaba, H., Greaves, M., & Mullighan, C. G. (2013). Acute lymphoblastic leukaemia. The
Lancet, 381(9881), 1943-1955.
Jayaraman, A., & Jamil, K. (2012). Clusters of CDK2, CCND1, and CMYC genes involved in
cancers: Acute Lymphocytic Leukemia (ALL) as a model. Biology and Medicine, 4(1),
37.
Pui, C. H., Yang, J. J., Hunger, S. P., Pieters, R., Schrappe, M., Biondi, A., ... & Escherich, G.
(2015). Childhood acute lymphoblastic leukemia: progress through collaboration. Journal
of Clinical Oncology, 33(27), 2938-2948.