Annotated Bibliography Portfolio 1: Bioengineering Research

This annotated bibliography explores the applications of 3D printing in bioengineering, focusing on medical phantoms, regenerated tissues, and organ-on-chips. The first reference, by Kan et al. (2017), reviews the use of 3D printing and bioprinting for creating functional medical phantoms, which are used for medical training, surgical planning, and device development. The annotation highlights the importance of high-fidelity, patient-specific models. The second reference, by Hee-Gyeong et al. (2017), discusses the use of 3D printing in creating organs-on-chips, which aim to mimic the complex physiological responses of real organs for drug testing. The annotation emphasizes the potential of 3D printing to control cell distribution and create miniaturized organs with specific functions. Both references offer recommendations for future research and development in the field of 3D printing for biomedical applications. The bibliography provides a list of the two cited sources.

Annotated Bibliography
Portfolio 1
Student’s name
Institution Affiliation(s)
Anno

Reference 1:
Kan, W., Chia-Che, H., Chuck, Z., & Ben, W. (2017). A Review of the 3D Printing of
Functional Structures for Medical Phantoms and Regenerated Tissue and Organ
Applications. Engineering, Vol 3, Iss 5, Pp 653-662 (2017), (5), 653.
doi:10.1016/J.ENG.2017.05.013 Access URL:
https://doaj.org/article/c568e58eebd74890a592d58e0438a587
Annotation: Medical models, or "ghosts," have been broadly utilized for medicinal preparing
and for specialist tolerant interactions. They are progressively utilized for surgical arranging,
medicinal computational models, calculation verification and validation, and restorative gadgets
improvement. Such new application request high-constancy, tolerant particular, tissue-mirroring
medicinal apparitions that cannot just intently copy the geometric structures of human organs,
yet additionally have the properties and functions of the organ structure. With the quick
headway of three-dimensional (3D) printing and 3D bioprinting innovations, numerous
scientists have investigated the utilization of these added substances producing systems to
manufacture functional medicinal apparitions for different applications. This paper audit the
applications of these 3D printing and 3D bioprinting advancements for the fabrication of
functional restorative apparitions and bio-structures.
Recommendation: This survey, particularly talks about the cutting edge along with new
improvements and patterns in 3D printed functional medicinal ghosts (i.e., tissue-copying
therapeutic apparitions, radiological significant restorative ghosts, and physiological therapeutic
apparitions) and 3D bio-printed structures (i.e., half-breed platform materials, convertible
frameworks, and incorporated sensors) for recovering tissues and organs.

Reference 2:
Hee-Gyeong, Y., Hyungseok, L., & Dong-Woo, C. (2017). 3D Printing of Organs-On-
Chips. Bioengineering (Basel), Vol 4, Iss 1, P 10 (2017), (1), 10.
doi:10.3390/bioengineering4010010
Access URL:https://doaj.org/article/9e00f40767a242058bcd3d9c256ce847
Annotation: Organ-on-a-chip building expects to make simulated living organs that copy the
mind-boggling and physiological responses of genuine organs, to test tranquilizes by
unequivocally controlling the phones and their microenvironments. To accomplish this, the
simulated organs ought to be micro-fabricated with an extracellular lattice (ECM) and different
kinds of cells, and ought to summarize morphogenesis, cell differentiation, and functions as
indicated by the local organ. A promising methodology is 3D printing, which accurately
controls the spatial distribution and layer-by-layer get together of cells, ECMs, and different
biometrics. Inferable from this novel preferred standpoint, integration of 3D printing into the
organ-on-a-chip building can encourage the creation of miniaturized scale organs with
heterogeneity, a coveted 3D cell course of action, tissue-particular functions, or even cyclic
development inside a microfluidic gadget.
Recommendation: Besides, completely 3D-printed organs-on-chips all the more effectively
consolidate other mechanical and electrical components with the chips, and can be popularized
by means of robotized monstrous production. In this, we examine the current advances and the
capability of 3D cell-printing technology in building organs-on-chips and gives the future points
of view of this technology to set up the very dependable and helpful medication screening
stages.

Bibliography
Hee-Gyeong, Y., Hyungseok, L., & Dong-Woo, C. (2017). 3D Printing of Organs-On-
Chips. Bioengineering (Basel), Vol 4, Iss 1, P 10 (2017), (1), 10.
doi:10.3390/bioengineering4010010
Kan, W., Chia-Che, H., Chuck, Z., & Ben, W. (2017). A Review on the 3D Printing of
Functional Structures for Medical Phantoms and Regenerated Tissue and Organ
Applications. Engineering, Vol 3, Iss 5, Pp 653-662 (2017), (5), 653.
doi:10.1016/J.ENG.2017.05.013