Australian Catholic University BIOL122 Annotated Bibliography

This assignment is an annotated bibliography focusing on asthma research. The document provides summaries of several research papers that explore different aspects of asthma, including its pathophysiology, genetic factors, and the role of various biological markers like YKL-40 and IgE-mediated allergy. The studies cover topics such as the comparison of asthma and COPD, the genetic pathways involved in asthma development, and the identification of internal and external factors contributing to asthma susceptibility. The bibliography includes research on the effects of YKL-40 levels, the prevalence of IgE-mediated allergy, and the evaluation of Th1/Th2 cytokine profiles in patients with severe bronchial asthma. Additionally, the annotated bibliography also discusses the limits and potential of genome-wide association studies in understanding asthma pathophysiology. This assignment aligns with the broader context of a vodcast presentation on asthma or type II diabetes mellitus, as part of the BIOL122 course at Australian Catholic University.

Running head: ANNOTATED BIBLIOGRAPHY
ANNOTATED BIBLIOGRAPHY
Name of the Student
Name of the University
Author note

1ANNOTATED BIBLIOGRAPHY
Annotated bibliography
Bonini, M., & Usmani, O. S. (2015). The role of the small airways in the
pathophysiology of asthma and chronic obstructive pulmonary disease. Therapeutic
advances in respiratory disease, 9(6), 281-293.
In this research study the researchers compared the studies conducted in the world and it
was found that the research was aimed to provide an updated and evidence based practice so that
they can use the detailed pathophysiology in the medication of the chronic obstructive
pulmonary disorder.
Grotenboer, N. S., Ketelaar, M. E., Koppelman, G. H., & Nawijn, M. C. (2013).
Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease
pathophysiology. Journal of Allergy and Clinical Immunology, 131(3), 856-865.
This research describes the genetic way using which asthma affects the issues. Therefore,
it describes the pathway using which the signals are dissects. This further leads to the chronic
asthma. Further, it also provided a complete pathway that was described in the research.
Melen, E., & Pershagen, G. (2012). Pathophysiology of asthma: lessons from genetic
research with particular focus on severe asthma. Journal of internal medicine, 272(2), 108-
120.
This research was determined to find out the internal and external factor which was
responsible for the occurrence of asthma and in the purpose, they conducted a large well‐

2ANNOTATED BIBLIOGRAPHY
designed study so that the occurrence of asthma could be identified. Therefore, it was determined
that genetic and environmental factors both are responsible for the asthma susceptibility.
Otsuka, K., Matsumoto, H., Niimi, A., Muro, S., Ito, I., Takeda, T., ... & Oguma, T.
(2012). Sputum YKL-40 levels and pathophysiology of asthma and chronic obstructive
pulmonary disease. Respiration, 83(6), 507-519.
In this research the primary aim of the researchers was to identify the effect of YKL-40
levels in asthma and COPD and therefore, for this purpose, 35 asthma patients, 14 nonsmoker
controls, and 45 patients with COPD was chosen for the research. Elevated level of YKL-40 was
seen in the asthma affected patients whereas in COPD the degree of its relevance was not found.
Rogala, B., Bozek, A., Gluck, J., & Jarzab, J. (2015). Prevalence of IgE-mediated
allergy and evaluation of Th1/Th2 cytokine profiles in patients with severe bronchial
asthma. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 32(4),
274.
In this research, the primary aim of the researchers was to identify the IgE-mediated
inhalant sensitization in acute asthma and it was found that in the group of patients with chronic
mild disease, the Th1 and Th2 due to which, the disease showed different severity.
Yoshikawa, T., Kanazawa, H., Fujimoto, S., & Hirata, K. (2014). Epistatic effects of
multiple receptor genes on pathophysiology of asthma–its limits and potential for clinical
application. Medical science monitor: international medical journal of experimental and
clinical research, 20, 64.

3ANNOTATED BIBLIOGRAPHY
This research was focused on the genome-wide association studies and for this, the
research provided a comprehensive research with proper sensitivity and hence, this was one of
the effective study to determine that by studding genetic study as well are not appropriate in
proving knowledge about the asthmatic condition in patients.