This report provides a detailed examination of the anatomy and biomechanics of bones and articular cartilage. It begins with an introduction to these connective tissues, emphasizing their roles in protection and support. The report then delves into the structure, development, and types of bones, including their cellular composition, organization, and functions such as movement, protection, and storage. The biomechanical properties of bones, bone growth, and remodeling are also discussed. The report further explores cartilage, covering its types (hyaline, fibrocartilage, and elastic), cells, tissues, and functions, particularly in the vertebral column. It also examines the biomechanics of joint cartilage and cartilage remodeling. Finally, the report analyzes the influence of pathological processes and anatomical variants on lower limb structure and function during walking and other activities, connecting gross anatomy and mechanical principles to bipedal function.