This report provides a comprehensive overview of the cultural anthropology of bubonic plague, exploring its origins, symptoms, and mortality rates. The report delves into the disease's history, including major outbreaks such as the Black Death, and examines the methods used to study it, such as skeletal analysis. It highlights the role of cultural anthropology in understanding how the disease was experienced and understood within historical and global contexts. The analysis includes a description of the disease, its symptoms, and mortality rates, as well as a case study analysis. The report also discusses the identification of the disease on skeletons through DNA analysis and the impact of the disease on human populations. References from the World Health Organization, and other academic sources are included. The report also provides insights into the living conditions and health statuses of people before and after plague outbreaks, based on skeletal evidence. Finally, it examines the study of the Black Death, including the potential role of pneumonic plague in its spread and the exclusion of rats as the primary vector of the disease.