This report presents a case study on Hilton Hotel, examining its utilization of Artificial Intelligence (AI) and Business Information Systems (BIS). It begins with an introduction to business information systems, highlighting their role in generating and disseminating information for decision-making. The report then explores the characteristics and global significance of AI, including feature engineering, neural networks, natural language processing, and computer vision. It also analyzes the organizational opportunities and challenges associated with AI implementation, such as AI in marketing, leveraging big data, and addressing concerns related to trust, data privacy, and security. The report provides an overview of Hilton's business, its information systems (TPS, DSS, EIS, and hotel automation), strategic positioning, and performance objectives. Furthermore, it discusses strategies for addressing trust, responsibilities, fairness, bias, and inclusion within the context of AI adoption. The report concludes with an assessment of how Hilton leverages AI to improve its business processes and achieve competitive advantages, emphasizing the importance of employee engagement and ethical considerations.