Review: CDTRP Progress Update Report for CIHR and Founding Partners

The report provides a comprehensive overview of the Canadian Donation and Transplantation Research Program (CDTRP), highlighting key accomplishments, sustainability strategies, and partnerships. The CDTRP has transitioned from a project-based structure to a national network supporting research collaborations. Key accomplishments include a new network name and the establishment of research themes and platforms. The report addresses sustainability through partnerships with national, provincial, and international organizations. The CDTRP partners with Canadian Blood Services, health charities, and industry leaders. Budgetary issues are identified, with deficits in certain years, prompting the search for new partnerships. The report also emphasizes the integration of AI and mathematical optimization in the field, including decision-making algorithms and research in imaging and pathology. The CDTRP is collaborating with global leaders to enhance transplantation science and decision-making techniques.

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Reviewing Canadian Donation and Transplant Research Program
Key Accomplishments
The CDTRP has launched a novel name for the network hence successfully reflecting
capacity-building in the donation research field the previous 5 years. Moreover, CDTRP has
formally transitioned from its original 7 Projects besides 4 Cores to the present revised as well as
redesigned 5 research Themes and 4 Platforms. The change network name to Canadian Donation
and Transplantation Research Program has made it effectively capture the significance as well as
equal weight of donation communities with transplant communities inside the national network
alongside patients and families. The management has also been optimized and in a firm stance
to drive its activities, resources and platforms to guarantee the network is delivering on its
anticipations to its communities.
Moreover, the CDTRP has also transitioned over the previous two years from a national
network funding a selected cohort of research projects to the presently national structure
supporting, enabling and fostering the development, execution, implementation as well as
translation of novel research collaborations and ideas. Thus, it is now an established “go to”
platform in Canada whereby investigators bring novel ideas to find patient partners,
collaborators, links to additional disciplines as well as individualized resources alongside
infrastructure support hence strengthening the research and surges the probability of success.

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Sustainability
The report comprehensively speak to the sustainability beyond the grant funding. For
instance, part of CDTRP sustainability strategy depends on the ongoing relationships as well as
collaboration with our national, provincial as well as international partners. Therefore, trans-
sector partnerships remains an imperative as well as integral constituent of this network; it
remains via strengthening as well as expansion of such relationships which CDTRP can move
discoveries into desirable leading practice which shall influence the lives of patients and
families. The CDTRP currently has more than 5-year history of success, showcasing its ability
to its national collaborative framework for delivering on its stated goals and objectives.
It has established diverse as well as productive partnerships with both private sector and
academic groups, placing it in a stance of leveraging this success into the subsequent round of
majority funding. This is being achieved by creating a formal coalition of its partners that have
vested interest in its ongoing research which might devote to another 5-years of funding with
huge cash as well as in-kind investments. It also aims at developing a strategic partnership with
Canadian Blood Services alongside CIHR to create a forma connection between the operational,
research as well as policy platforms at national level. This is envisioned that collaboratively,
CBS, CDTRP alongside CIHR would ultimately build a collaborative vision as well as seek
lasting funding from provincial or federal governments to back health or clinical services besides
research in donation as well as transplantation.
Partnership
The CDTRP has brought together over three hundred scientists, collaborations, students,
patient and family partners alongside knowledge users at thirty-three sites throughout Canada.

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The partners and stakeholders of CDTRP entails all of the Canada’s large donations as well as
transplantation charities alongside federal besides provincial governments, start-ups, pharma and
technology industry as well as an expanding number of international collaborators.Some of the
key partnerships include Canadian Blood Services (CBS), Canada’s largest health charities,
professional societies (international and national) and research groups.
Budget Issues
The CDTRP’s current budget seems not be sufficient. This is why the CDTRP is seeking
for new potential partnerships which can commit for the next five years. These potential partners
encompasses research-intensive universities, health charities, professional societies, alongside
multi-national industries including Novartis, Roche, and Astellas in Pharma. Others include
provisional government agencies alongside a renewed interest from federal government via
Health Canada and Organ Donation and Transplant Collaborative.
As seen under the anticipated funding, it is clear that the budget is deficit and hence not
meeting the anticipated. For instance, in year 2 and 3, there were deficit budgets of -327049 and -
200170 while in year 4, all the budget amount went for anticipated spending leaving a zero
balance. Thus, the cumulated balance after committed and anticipated were surplus in years 1
and 2 but stood deficit of -191368 and -191368 in year 3 and 4. The infrastructure amount left
was a deficit of -191368 after both committed and anticipated.
Other Key Points
CDTRP is in the track in terms of the realization on the benefits of the AI and
mathematic optimization in the donation and transplantation field. For example, decision-making
algorithms have an integral part of allocation of organ beginning the earliest periods of
transplantation. Thus, CDTRP is increasingly exploring the explosion of advancements in

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computing sciences recently and hence acknowledging the AI’s role in this field due to its
potentiality in revolutionizing diagnostic process, whereby intense research activities in imaging
and pathology remain underway. Moreover, decision-making process alongside problem
predicton might stay readily tackled utilizing AI and mathematical optimization. This has
informed the decision by CDTRP to build ongoing collaboration with global leaders Andrea
Lodi alongside Yoshua Bengio on projects linked to transplantation science alongside decision-
making techniques for offer acceptance for deceased donor kidneys alongside donor death
prediction via brain-wave analysis.