Research Report: Chemotherapy Side Effects on Cancer Patients Study

This report presents a study protocol evaluating the side effects of chemotherapy on cancer patients. It begins with an introduction and background on chemotherapy as a cancer treatment, its benefits, and its potential side effects, such as immune suppression, fatigue, and organ damage. The report outlines the rationale, significance, and theoretical frameworks, including themes on the chemotherapy method, its application, and its impact on patients' health. It details the research aim, objectives, and questions, followed by the study design, data collection, and analysis methods. The study settings, sample, recruitment process, and eligibility criteria are also described. Furthermore, the report addresses ethical and regulatory considerations, dissemination policy, and a Gantt chart for the study timeline. Finally, it provides a comprehensive list of references used in the study, offering a detailed overview of the research on chemotherapy's effects on cancer patients.

CHEMOTHERAPY'S SIDE
EFFECTS ON CANCER
PATIENT

TABLE OF CONTENTS
STUDY PROTOCOL......................................................................................................................4
INTRODUCTION...........................................................................................................................4
BACKGROUND.............................................................................................................................4
RATIONALE..................................................................................................................................5
Significance.................................................................................................................................5
THEORETICAL FRAMEWORKS.................................................................................................6
Theme 1 The concept of chemotherapy method..........................................................................6
Theme 2 Application of chemotherapy for treating cancer patients............................................7
Theme 3 Side effect of chemotherapy on cancer patient.............................................................8
Theme 4 Negative effect impact on the health and treatment of cancer patient..........................9
RESEARCH AIM, OBJECTIVES AND QUESTIONS.................................................................9
Aim..............................................................................................................................................9
Objective......................................................................................................................................9
Research question........................................................................................................................9
STUDY DESIGN AND METHOD OF DATA COLLECTION AND DATA ANALYSIS........10
Study Design..............................................................................................................................10
Data Collection Methods...........................................................................................................10
Data Analysis Methods..............................................................................................................10
STUDY SETTINGS......................................................................................................................11
SAMEPLE AND RECRUITMENT..............................................................................................11
Eligibility Criteria......................................................................................................................11
Sampling....................................................................................................................................12
Recruitment................................................................................................................................13
Outcomes...................................................................................................................................14
ETHICAL AND REGULATORY CONSIDERATIONS.............................................................14
Assessment and management of risk.........................................................................................14
Research Ethics Committee (REC) review & reports...............................................................14
Peer review................................................................................................................................15
Patient & Public Involvement....................................................................................................15

Regulatory Compliance.............................................................................................................15
Protocol compliance..................................................................................................................16
Data protection and patient confidentiality................................................................................16
Indemnity...................................................................................................................................16
Access to the final study dataset................................................................................................16
DISEMMINATION POLICY.......................................................................................................16
Dissemination policy.................................................................................................................16
Authorship eligibility guidelines and any intended use of professional writers........................16
GANTT CHART...........................................................................................................................17
REFERENCES..............................................................................................................................18

STUDY PROTOCOL
To evaluate the chemotherapy's side effects on cancer patient.
INTRODUCTION
As the number of cancer patients in the world keeps on steadily increasing, healthcare
professionals around the world are steadily recommending increasing number of cancer patients
to undergo chemotherapy as a viable treatment method for countering cancer. Chemotherapy is a
cancer treatment method that makes use of singular or multiple anti-cancer drugs with the
intention to either prolong the remaining life patient suffering from critical stages of cancer or to
cure patients in initial phases of cancer (Oun, Moussa and Wheate, 2018). The anti-cancer drugs
used in chemotherapy are designed with the intention to introduce them directly into the patient’s
blood stream so that the anti-cancer drugs can address cancer in the patient’s body irrespective of
the anatomic location of the cancer present over the patient’s body.
Though it has been proven that cancer can be treated effectively through the use of
chemotherapy method, chemotherapy treatment can also result in various side effects for the
patient such as immune suppression which is the condition where the patient’s immune system
gets suppressed, which happens due to the paralysing of bone marrow, resulting in a reduction in
the patient’s red, white blood cells and platelets (Demaria and et.al., 2017). As the immune
system becomes suppressed, the patient can suffer from Typhlitis, which is a condition where the
patient’s intestine get infected and presents itself through symptoms such as vomiting, nausea,
diarrhoea, chills, fever etc. for the patient. Other side effects of chemotherapy also include
fatigue, vomiting, hair loss, infertility, organ damage etc.
BACKGROUND
Chemotherapy can be defined as the drug treatment in which uses potential chemicals to kill
or prevent fast-growing cells or tissue in the body. It is most often use to diagnose cancer till
cancer cells grows faster and multiply more quickly as compared normal cells. Chemotherapy
treatment is quite painless but several chemicals which are more powerful causes feels slight
burning when they enter into veins. Chemotherapy means chemical therapy which is given to
those patients who suffers from cancer disease. The disease shows characteristic to enhance
growth of unwanted cell and kills normal cell to growth. While chemotherapy helps to kill these
unwanted cells by using powerful chemicals (Rubinsak and et.al., 2019). So, it gives side effects
in human body but doesn’t harm body functioning. The working of chemotherapy is quite
4

simplest process such as it is initially targeted specified sells which grows and divide quickly as
cancer tissues do. Radiations are passed from the certain areas where chemo works on the cell
throughout body. Specifically, chemotherapy doesn’t cure cancer properly but it supports in the
other type of combination along with different type of treatment i.e. breast cancer, mouth cancer
and others. where chemotherapy reduces risk of cancer by treating with chemicals after surgery.
Chemotherapy is used by various cancer hospitals to treat different type of cancer patients. They
get side effects of chemotherapy such as loss of appetite, bowel issues i.e. constipation and
diarrhoea which is quite common, mouth sores, nail problem, hair loss and nausea. It gives
impact on the memory of cancer patient and they unable to remember things. Listening problem
also occurs in patient due to chemotherapy. Even most of the time chemotherapy increases risk
of infection in the cancer patient due to high chemical treatment.These is the side effect which
suffers by cancer patient while taking chemotherapy.
RATIONALE
The research is on side effects of chemotherapy on cancer patients. It is spot topic from past
few years because many of the patients who suffer from cancer disease have to face side effect of
chemotherapy. This method is highly popularized from several years which are used by various
cancer hospitals to treat cancer patients. But chemotherapy gives harmful side effect in human
body which causes get impairment in the body functioning. So, it is needed to research on the
topic to analyse cancer patient condition and impacts of chemotherapy.
Significance
The research topic has wide scope in the science field because it is highly demanding
topic. Primary care of cancer is available overall the world but last stage of cancer doesn’t have
cure still. Even chemotherapy which is used by various cancer centre to treat cancer but gets
more side effect on normal cell that causes have to face inconvenience by cancer patient. So, this
research helps other researchers and cancer centre and people to know about chemotherapy side
effect on cancer patient.
The purpose of this research paper is to evaluate the side effects of chemotherapy on Cancer
patients. This is of immense significance to the healthcare industry, organisation and
professionals as the number of cancer patients in the world keeps increasing and the side effects
to the most common treatment of Cancer should be publicly available for patients and healthcare
professionals to make an informed decision about the treatment process.
5

THEORETICAL FRAMEWORKS
Theme 1 The concept of chemotherapy method
As per the view of Oun, Moussa and Wheate, (2018) it is an aggressive form of
chemicals which is used for drug therapy. In simple word, it is used to destroy rapidly growing
cells in the body. The method is basically is used to treat cancer. It is used in combination with
different therapies i.e. surgery, hormone therapy or radiation therapy as per types of cancerous
cell. Cancer is disease which has various types such as mouth cancer, brain cancer, breast cancer,
skin cancer etc. and it became challenge for the world because it is fast growing cell disease that
directly leads death of human. Chemotherapy method stops cancerous cell to multiple growth by
interfering continuously by the drug. Chemotherapy is used to treat different stage of cancer but
specifically stage four cancer which is known as advanced cancer. This method plays essential
role in the cancer disease because it used to lower the total number of cancer cells in the cancer
patient body. It declines the likelihood of cancer spreading. It shrinks tumour size as well which
is not possible by surgery and others.
However, perspectives of writer Madmoli, (2018) have criticized about chemotherapy in
their published research paper. Chemotherapy is highly expensive method which is not
affordable for every cancer patient. It is more harmful for the cancer patient who takes
chemotherapy treatment to treat their cancer because it gives negative impact on their health.
Chemotherapy is the prescribed treatment for patients suffering from various stages of
cancer. It is a type of chemical drug therapy that is used on patients with the intention to
effectively and efficiently destroy the harmful and hazardous cancer cells and keep them from
multiplying to bigger sizes. As the cancer cells have a great multiplication rate and can
effectively double in a short period of time, chemotherapy treatment is preferred by healthcare
professionals to rapidly destroy cancer cells in the patient’s body and to avoid any further
increased damage from cancer (Poulopoulos, Papadopoulos and Andreadis, 2017). Though
chemotherapy is effective, its prescribed treatment by healthcare professionals is done in
combination or addition to other therapies designed to counter the cancer cells from wreaking
havoc inside the patient’s body such as radiation, surgery, hormone therapy etc. The combination
of the treatment is totally dependent on the patient’s health, growth of cancer in body, organ
which has been infected etc. Chemotherapy is widely used by healthcare professional due to its
ability to reduce cancer cells from multiplying and spreading, shrink tumour size by reducing the
6

number of cancer cells present in the body which can help the patient recover or at least provide
him with more time with which other treatment methods can be tried (Aguilera Braico, Roldán,
Deamicis and Brie and Balogh, 2017).
Theme 2 Application of chemotherapy for treating cancer patients
As illustrated by Banach, Juranek and Zygulska, (2017) chemotherapy method is
worldwide famous method but uses in several cancer hospital because it carries high cost and
needs experts who can use specifically to treat cancer. The point is to discuss that why use
chemotherapy for treating cancer. the reason behind is that it is systematic process and use
chemical to destroy fast growing cell in the body. It is fast method instead of others like
medication because it is directly targeted certain area where unwanted cell growing number of
cancer cell. In the past years several chemical drug is used to treat only certain type of cancer but
standard type chemotherapy is quite different from traditional type chemo method. Standard type
chemotherapy uses large combination of different chemicals for treating different type of cancers
which works more better as compared past chemo method. The main goal of the chemotherapy
in the cancer treatment is to cure, control and palliation of cancer forever. Palliation is the
advanced stage of cancer which directly lead death but chemotherapy uses to prevent growth of
cancerous cell in the stage.
However, some authors have quoted in their published article about chemotherapy side
effect. This method is used to treat different type of cancer as well last stage of cancer but has
more side effect like risk of infection, impairment in organ functioning, drug interaction etc. it is
not good method to use over for the cancer patients.
Though chemotherapy is prescribed regularly by healthcare professionals as an effective
and efficient treatment for patients suffering from various stages of cancer, it can have major side
effects on the physical and mental health of the patients (Widianti, Yona and Waluyo, 2019).
Many of these are quite common to occur with patients undergoing the chemical drug therapy
that is chemotherapy, which can additionally hamper their body’s functioning though taking care
of their cancer. The most common side effects amongst patients is weight loss, hair loss, nausea,
vomiting, loss of appetite, insomnia, which can be relatively easily cured by adequate healthcare
services. Contrastingly, some side effects of chemotherapy can have major side effects on the
immune systems of patients, as the drugs used in chemotherapy tend to suppress the immune
systems of patients, which makes them increasingly susceptible to various kinds of infections,
7

suffer excessive pain from nerve damage and undergo excessive bruising and bleeding in cases
of even minor injuries or scratches. Another major side effect of chemotherapy is its tendency to
make the patients infertile as many types of chemotherapies are gonad toxic in nature.
Theme 3 Side effect of chemotherapy on cancer patient
According to Alexander and et.al., (2017) chemotherapy is good method to treat cancer
and main thing it and be used in last stage as well for stopping growth of cancerous cell. But it
causes more side effects in cancer patients’ body like they get irritation in their skin after taking
chemotherapy treatment because sometime uses powerful chemicals to target cancer cell which
leads burning sensation in veins. It causes losses of hair due to high utilization of number of
chemicals for destroying cancer cells as result weak hair follicles. Nausea and vomiting also
consider into side effect of chemotherapy.
According to cancer doctors, chemotherapy leads dietary change which directly reduces
their appetite but it can recover by giving appetizers and anti-nausea medicines. Constipation and
diarrhoea is quite common side effect which occurs due to chemotherapy because it triggers
digestion cells while targeting cancerous cells. The method gives pain in patient body like
headache, muscle pain and stomach pain which generally occurs when nerve cells are damaged.
So it can say chemotherapy damages nerve such as burning, numbness etc.
The negative side effects of chemotherapy have lasting and immense impact on the
physical and mental health of patients suffering from various stages of cancer (Uzun and Kucuk,
2019). As many types of chemotherapies used by healthcare professionals are gonad toxic in
nature, it effectively suppresses the patient’s immune system operations making them
increasingly susceptible to major infections and diseases from minor cuts, scratches and bruises.
This has an immensely negative impact on the patient’s outdoor and social life, as patients are
constantly scared of getting bruises and scratches from minor outdoor incidents. This also has an
immensely negative impact on their mental health as they also cannot enjoy the freedoms that
they used to cherish prior to being diagnosed with cancer (Tian and et.al., 2019). Infertility
amongst interested women and mothers is another major cause of distress and depression
amongst the female patients, adding to the enormous stress of cancer, which affects them both
physically and mentally. In addition, many times chemotherapy results in impairing of cognitive
reasoning for its patients which not only results in them losing ability to perform daily duties
8

effectively, also places quite a burden on their family and friends, further affecting the mental
wellbeing of the patient suffering from cancer.
Theme 4 Negative effect impact on the health and treatment of cancer patient
As per the view of Eghbali and et.al., (2016) there are several adverse effects of
chemotherapy includes early menopause and weight gain and often leads heart problem and
leukaemia as well. These are long-term side effect of chemotherapy which directly gives
negative impact on the health of cancer patient. Due to long-term side effect, it is impossible to
give chemotherapy according to process. Patient gets negative impact on their memory because
they face difficulties to memorize things. Immune system become of patient after chemotherapy
because immune cell get damage while radiation treatment. That why, the risk of serious
infection enhances in the cancer patient. They brush and bleed more easily by simple slashes
which are also considered into side effect because clotting agents are damaged by
chemotherapies. another impact of the method on the patient health is that they get trouble in
breathing because it damages lungs, declines its capacity which makes harder to get oxygen
when they need. It causes get rashes on patient body which causes they can’t go in sunlight due
to high burning sensation.
Other perspectives, Hammel and et.al., (2016) has given several suggestion to overcome the
side effects in their publishes articles. Side effect can overcome when patient follows overall
direction of doctor which they give because each chemical has own property i.e. allergic or
pungent. In that situation needs to consult with doctor about their issues so that can get rid off
over the time.
RESEARCH AIM, OBJECTIVES AND QUESTIONS
Aim
To evaluate the side effects of chemotherapy on Cancer patients
Objective
 To assess the effectiveness of chemotherapy methods in treating Cancer patients.
 To evaluate the side effects chemotherapy can have on cancer patients.
 To analyse ways in which negative effects of chemotherapy impact the health and treatment
of Cancer patient.
Research question
 Why chemotherapy is used to treat Cancer patients?
9

 What are the side effects of chemotherapy on Cancer patients?
 How negative side effects impact the health and treatment of Cancer patient?
STUDY DESIGN AND METHOD OF DATA COLLECTION AND DATA
ANALYSIS
Study Design
The study design helps in ascertaining what kind of study will be undertaken i.e. the
manner in which evidences will be collected and analysed in order to conduct a research
satisfactorily where relevant and meaningful results are drawn from the collected data (Biswal
and Mehta, 2018). The data collection method as well as the data analysis methods basically
depends on the kind of research design that is being chosen for the intended research. The
current research is descriptive research where the systematic review on chemotherapy and its
impact on the cancer patients will be evaluated by using this research design.
Data Collection Methods
Data will be collected through secondary data collection techniques. The secondary
research will be conducted by assembling the relevant literature that has been published through
case studies, journal and other relevant articles etc. (Daniel and et.al., 2019). This will help in
synthesis of all the relevant details that can be collected for the research in the form of already
published literature and data. The selection of the papers would be on the basis of relevance of
the data that has been published and the effectiveness with which it will contribute in the existing
research of side effects of chemotherapy. Therefore, in the research collectively, secondary data
collection methods will be used for the process of completing research related to the impact of
chemotherapy and its side effects on the cancer treatment. This will ensure that the data collected
for the research is meaningful and helps in producing relevant results that can effectively
contribute in the purpose with which research is being conducted.
Data Analysis Methods
After the identification of the correct literature paper, i.e. research papers, articles o case
studies that can help in completion of effective research, helping in the achievement of
objectives, it is necessary to develop a proper mechanism for analysing the papers thus collected.
Systematic review technique can be adopted where the different aspects related to the collection
of the literature review will be evaluated on the basis of different themes that will be formulated
accordingly. Here the thematic analysis helps in formulation of different themes that can be used
10

to develop appropriate concepts, findings etc. according to the theme that has been developed
(Abdulkareem and et.al., 2019). The research is presented in a simplified and attractive manner
where it can easily be interpreted without many complications. The interpretation gets easier
when the thematic analysis technique is used and this can be done in an impactful manner by
interpreting the results that have been recorded.
STUDY SETTINGS
The study setting can be used to ascertain that the manner in which the data will be collected
and further the justification of the selected approached for accessing the different research papers
relevant to the research and then adequately select them on the basis of the eligibility criteria
(Jungk and et.al., 2016). In the current research that is to be conducted on the side effects of
chemotherapy specifically in cancer patients will involve selection of the systematic review as
the study method where only secondary research will be completed and that too through the
different literature review and research papers that have already been published on the topic. The
research will be a completely secondary study and therefore it will become easier to collect the
data even through the different technological or other modes of assistance so that correct papers
that will contribute significantly can be used or collected (Yulianasari, Haniyah and Susanti,
2020). Additionally, there are no further specific requirements that need to be taken in
consideration for collecting the samples that will be required on the site. Therefore, the limited
area of side effects of chemotherapy only on cancer patients within which the research is being
conducted will help in the collection of complete data from the selected papers thus forming a
part of comprehensive research.
SAMEPLE AND RECRUITMENT
Eligibility Criteria
The eligibility criterion helps in ascertaining which are those research papers that are
eligible to be included in the research. This collectively includes all the research papers that have
been published on the relevant topic that can qualify to be included in the research that has been
proposed on the chemotherapy and its side effects (García-Chías and et.al., 2019). The research
papers with the sample of patients that have undergone through the chemotherapy and its impact
on the cancer patients who have actually undergone through the treatment through this cancer are
the best constituents as the part on which the research of this topic on the side effects of
chemotherapy on cancer patients. Out of this abundance of research papers on side effects of
11

chemotherapy there will be some common points on the basis of which some research papers
will be included as selected ones in the systematic research and others will be excluded.
Inclusion Criteria
The proposed research is on study of the certain side effects from the chemotherapy
treatment that has been given to the cancer patients. The papers that will be selected will be
based on the type of sample on whom study has been conducted i.e. it should mainly be on the
cancer patients regardless of the age, gender etc. papers will be selected on the analysis and study
that has been done on the different consequences that they have faced due to the chemotherapy
that they received (Widianti, Yona and Waluyo, 2019). The clinical conditions of the patients
selected in the sample would be mainly analysed along with the additional treatment that they
might have underwent through because of the side effects that occurred on such patients involved
in chemotherapy. However, only the quantitative papers that adequately address and satisfy
different aspects related to research on the cancer patients and have been developed in recent five
years will be selected rather than the selection of all the papers that have been published.
Exclusion Criteria
In the proposed research, all the research papers on patients who have underwent
chemotherapy will not be included and there are certain criteria on the basis of which majority of
the papers would be excluded from the proposed research. The first exclusion criterion is the
publishing journals or magazines, i.e. articles that are not published in some authentic books or
journals will be excluded immediately on the basis of lack of authenticity (Johnson and Haag,
2019). Additionally, systematic research papers on those patients who have not suffered any side
effects due to chemotherapy would also not be included in the research. Also, the research papers
which were published long back and the effects are no longer considered as major effects or have
completely vanished cannot be included in the research because of the redundancy that they will
render in the research. Therefore these are the criteria on whose basis there will be exclusion of
certain categories of published research papers.
Sampling
The technique of sampling helps in ultimately determining and ascertaining the selection of
a fewer eligible research papers who will ultimately contribute towards the conducting of a
comprehensive research. This is the most critical step as it helps in ascertaining that relevance
and validity of the research because the selected research papers will be used to interpret and
12

draw major conclusions satisfying the purpose of the research that has been taken currently
(Absolom, Gibson and Velikova, 2019). This involves evaluation kind of sample that has been
included in the systematic review and further the prisma flow chart technique will be used to
collect the intended number of systematic review papers. This will collectively help in
developing a comprehensive research methodology and data collection methodology.
Recruitment
The recruitment aspect in sampling helps in ascertaining that how the intended systematic
review papers that are required for the successful completion of the research will be identified
collected and selected for the purpose of conducting research. It is necessary that the papers
selected are authentic and will contribute meaningfully in the research. Therefore this aspect is
very critical in ensuring that the research papers selected will lead to the development of
meaningful conclusions that will help in generating meaningful conclusions that are required to
ensure that they contribute in the field of ascertaining side effects of chemotherapy on cancer
patients (Vega, Dumas and Newhouse, 2017). Effective selection of the research papers can be
done by identifying the kind of research that has been conducted on the side effects of
chemotherapy on cancer patients and also obtaining their consent which is extremely necessary
to prove that the research does not incorporate plagiarism of any kind in the research. This can be
further expanded on both the points.
Sample Identification
The systematic review papers that are to be comprehensively included in the research will
be identified by the researcher themselves and this will be done through the technique of critical
analysis. The researchers will identify all the research papers that have been published on the
side effects that the cancer patients were found to have developed during the chemotherapy
sessions. These will be identified and collected through technological means were the researcher
will research through different papers published on various journals and then select the ones that
are found ot be most appropriate (Altun and Sonkaya, 2018). Only the research papers published
in the past five years will be selected for the purpose of systematic review and then further, the
sole focus would be on identification of the systematic research papers on chemotherapy. This
will quicken the process of selecting relevant research papers very quickly and thus the process
will become effective as well helping in collection of relevant and authentic research papers.
Consent
13

Obtaining the consent of the authors of the research that have been by the researcher is very
important and comprehensive part of the research. There will be a written signed form that will
state that the author has willingly given the permission to the research to use their work for
completing the intended research and therefore they will be given proper authority to use their
work wherever found appropriate in the research. Additionally the researcher themselves will
also present a declaration form at the starting of the research stating that all the authors have
been properly cited wherever external references have been taken of the secondary data
published by authors (Gholamzadeh and et.al., 2019). Further, the researcher will also declare
that the work carried out is original and has been performed by them only. All the declarations
and consent form will be completely legalised by the authentic signatures of both the parties i.e.
the researcher and the authors so that no legal trouble over originality of the report can arise in
future.
Outcomes
From the systematic review that was done on the research papers evaluating the different kind of
side effects that were studied by different authors, the overall conclusion or finding that was
drawn is the majority of the patients who take chemotherapy are affected in some manner or
another. Further, it was also evidenced from the studies that the side effects can range from
extremely severe to almost negligible depending on various body factors that differ between each
individual.
ETHICAL AND REGULATORY CONSIDERATIONS
Assessment and management of risk
There are no risk associated related to conduction of research as patient are not asked such
question that are harmful their health and may cause distress. While conducting research health
of patient are considered on priority basis and all ethical rules and regulation are followed to
ensure health and safety of patients. At the same time any such information was not disclose that
with harm other people and information in exchange by reducing its associated risk to minimum.
Research Ethics Committee (REC) review & reports
Yes, before conducting research on chemotherapy's side effects on cancer patient
permission from Research ethics committee had been taken to avoid stoppage of research in
future time. All rules and regulation made by research ethic committee are followed by us while
14

research that helps in effective study and analysis of data and information (Brandhorst and et.al.,
2017). Various amendments are reviewed by Research ethics committee and research and
development department before implementation in practice.
Peer review
While conducting research review of peer one are not taken to make research effective and
appropriate so that best outcome can be gained within minimum cost. To make research valid
secondary data were used instead of primary method to save time and effort. It helps in making
information accurate and correct as valid source such as books, journal and article of highly
skilled and knowledge scientists for better research of the topic.
Patient & Public Involvement
While analysis data and information to know about side effect of chemotherapy's on cancer
patient’s we have use secondary data such as previous experience of patients in an article.
Various articles, books and journal are used to know about Ideas, view of patient and its family
member to know that what things that happen after chemotherapy's so that various ways that can
be wound out too avoid such circumstance in future. Large number of data was collected in
reviewing experience of chemotherapy's in order to make aware other people about such
disadvantages that impact health of individual adversely (Gandhi. and et.al., 2018).
Regulatory Compliance
Compliance of regulatory framework is another procedure for conducting research in
ethical manner so it had been followed while researching about specific information (Custódio,
and et.al., 2016). Various regulatory and laws made by National health services research and
development department helps in collecting accurate data and information about side effects of
chemotherapy's on cancer patients through use of secondary data such as books and journal.
Protocol compliance
As protocol can be happen at any time so are documented and are immediately send to
Chief Investigator and sponsor of research to avoid serious breach. Research was conducted by
compliance with various protocols for approval of protocol by senior authorities.
15

Data protection and patient confidentiality
Different act related to safety and security of data that need to be followed during research
analysis of side effect of chemotherapy's on cancer patients such as Data protection Act. Staff
member were strictly abided to legal laws and policy of company while collection, storage,
processing and disclosure of information. Secured medium and technology were used to store
data that have strong password to avoid leakage of personal information and harm to other
people.
Indemnity
Insurance or indemnity of staff member has been done in order to avoid potential legal
liability of sponsors. Various compensation pay have been made in case of harm to research
participants.
Access to the final study dataset
The data and information gathered while conducting research can be used by people that want to
know about side effects of chemotherapy's on cancer patients. It can also be accessible to those
who want to further conduct such research to better know about such information for public
benefits.
DISEMMINATION POLICY
Dissemination policy
The data is owned and controlled by individual that have conducted research on side
effect of chemotherapy's on cancer patients and it can be accessed through online sites (Dai and
et.al., 2017). Yes, supporting body are provide appropriate knowledge about publication rights
of data.
Authorship eligibility guidelines and any intended use of professional writers
There are various guideline and eligibility criteria for gaining authority of intended use of
professional writers so that data can be owned by particular individual. Authority eligibility
criteria were defined by international committee of medical journal Editors.
GANTT CHART
Task Mode Task Name Duration Start Finish Predecessors
Manually
Scheduled
Systematic review on Side
effects of chemotherapy 43 days Fri 3/20/20 Tue 5/19/20
Auto Research methods selection 4 days Fri 3/20/20 Wed 3/25/20
16

Scheduled
Auto
Scheduled Theoretical frameworks 7 days Thu 3/26/20 Fri 4/3/20 2
Auto
Scheduled
Developing aim and objective
for research 3 days Mon 4/6/20 Wed 4/8/20 3
Auto
Scheduled
Developing study design and
sampling methods 5 days Thu 4/9/20 Wed 4/15/20 4
Auto
Scheduled Collecting of secondary data 7 days Thu 4/16/20 Fri 4/24/20 5
Auto
Scheduled Outcomes of systematic review 4 days Mon 4/27/20 Thu 4/30/20 6
Auto
Scheduled
Conclusion and
Recommendation 3 days Fri 5/1/20 Tue 5/5/20 7
Auto
Scheduled Formatting 2 days Wed 5/6/20 Thu 5/7/20 8
Auto
Scheduled Taking feedback 3 days Fri 5/8/20 Tue 5/12/20 9
Auto
Scheduled
Doing changes as per the
feedback provided 4 days Wed 5/13/20 Mon 5/18/20 10
Auto
Scheduled Final submission 1 day Tue 5/19/20 Tue 5/19/20 11
17

REFERENCES
Books and Journals
Abdulkareem, A.G., and et.al., 2019. Chemotherapy-related side effects in childhood cancer in
Hiwa Hospital Sulaimani city. Kurdistan Journal of Applied Research, pp.182-189.
Absolom, K., Gibson, A. and Velikova, G., 2019. Engaging patients and clinicians in online
reporting of adverse effects during chemotherapy for cancer: the eRAPID system
(electronic patient self-reporting of adverse events: patient information and
aDvice). Medical care. 57. pp.S59-S65
Aguilera Braico, D.M., RoldánDeamicis, A., Brie, B. and Balogh, G.A., 2017. Comparative
Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment.
Alexander, J.L and et.al., 2017. Gut microbiota modulation of chemotherapy efficacy and
toxicity. Nature Reviews Gastroenterology & Hepatology. 14(6). p.356.
Altun, I. and Sonkaya, A., 2018. The Most Common Side Effects Experienced by Patients Were
Receiving First Cycle of Chemotherapy. Iranian journal of public health. 47(8). pp.1218-
1219.
Banach, M., Juranek, J.K. and Zygulska, A.L., 2017. Chemotherapy‐induced neuropathies—a
growing problem for patients and health care providers. Brain and behavior. 7(1).
p.e00558.
Biswal, S.G. and Mehta, R.D., 2018. Cutaneous adverse reactions of chemotherapy in cancer
patients: A clinicoepidemiological study. Indian journal of dermatology. 63(1). p.41.
Brandhorst, S., and et.al., 2017. Protective effects of short-term dietary restriction in surgical
stress and chemotherapy. Ageing research reviews, 39, pp.68-77.
Cascella, M., 2017. Preoperative cardiac evaluation and anesthetic considerations for cancer
patients who underwent chemotherapy. Trends in Anaesthesia and Critical Care, 14,
pp.9-18.
Custódio, I.D.D and et.al., 2016. Impact of chemotherapy on diet and nutritional status of
women with breast cancer: a prospective study. PLoS One, 11(6).
Dai, Y.L and et.al., 2017. Changes in and determinants of quality of life in patients with
advanced non-small-cell lung cancer undergoing initial chemotherapy. journal of nursing
research, 25(3). pp.203-215
18

Daniel, J.M., and et.al., 2019. Assess the knowledge on side effects of chemotherapy among
caregivers of cancer patients. Religion. 86. p.86.
Demaria, M and et.al., 2017. Cellular senescence promotes adverse effects of chemotherapy and
cancer relapse. Cancer discovery. 7(2). pp.165-176.
Eghbali, M and et.al., 2016. The effect of auricular acupressure on nausea and vomiting caused
by chemotherapy among breast cancer patients. Complementary therapies in clinical
practice. 24. pp.189-194.
Gandhi, L. and et.al., 2018. Pembrolizumab plus chemotherapy in metastatic non–small-cell lung
cancer. New England Journal of Medicine, 378(22). pp.2078-2092.
García-Chías, B., and et.al., 2019. Prevalence of oral side effects of chemotherapy and its
relationship with periodontal risk: a cross sectional study. Supportive Care in
Cancer. 27(9). pp.3479-3490.
Gholamzadeh, H., and et.al., 2019. Effect of reflexology on the side effects of chemotherapy in
cancer patients: an integrative review. Evidence Based Care. 8(4). pp.7-13.
Hammel, P and et.al., 2016. Effect of chemoradiotherapy vs chemotherapy on survival in
patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine
with or without erlotinib: the LAP07 randomized clinical trial. Jama. 315(17). pp.1844-
1853.
Johnson, P. and Haag, C., 2019. The Yoga Mat, Where East Meets West: A Pilot and Feasibility
Study Evaluating a Structured Yoga Practice on Common Side Effects of
Chemotherapy/Biotherapy in Cancer Patients. Journal of Oncology Navigation &
Survivorship. 10(9).
Jungk, C., and et.al., 2016. Chemotherapy with BCNU in recurrent glioma: Analysis of clinical
outcome and side effects in chemotherapy-naïve patients. BMC cancer. 16(1). p.81.
Madmoli, M., 2018. Evaluation of chemotherapy complications in patients with cancer: A
systematic review. International Journal of Research Studies in Science, Engineering and
Technology. 5(12). pp.59-64.
Oun, R., Moussa, Y.E. and Wheate, N.J., 2018. The side effects of platinum-based chemotherapy
drugs: a review for chemists. Dalton transactions. 47(19). pp.6645-6653.
Poulopoulos, A., Papadopoulos, P. and Andreadis, D., 2017. Chemotherapy: oral side effects and
dental interventions. A review of the literature. Stomatological Dis. Sci, pp.2573-0002.
19

Rubinsak, L.A and et.al., 2019. Reproductive health care across the lifecourse of the female
cancer patient. Supportive Care in Cancer. 27(1). pp.23-32.
Tian, Xand et.al., 2019. Role of Progressive Muscle Relaxation in Preventing and Alleviating of
Nausea and Vomiting Caused by Chemotherapy among Cancer Patients: A Systematic
Review of Six Randomized Controlled Trials.
Uzun, Z. and Kucuk, S., 2019. Side effects of chemotherapy in children with cancer: effects of
nursing training administered to caregivers. Australian Journal of Advanced Nursing,
The. 36(4). p.37.
Vega, J.N., Dumas, J. and Newhouse, P.A., 2017. Cognitive effects of chemotherapy and cancer-
related treatments in older adults. The American Journal of Geriatric Psychiatry. 25(12).
pp.1415-1426.
Widianti, M.O., Yona, S. and Waluyo, A., 2019. Body Image, Social Support, Effects of
Chemotherapy, and Sexual Desire in Breast Cancer Patients. Journal of International
Dental and Medical Research. 12(1). pp.323-330.
Yulianasari, E., Haniyah, S. and Susanti, I.H., 2020, February. The Effect of Acupressure
Wristbands Toward Acute Nausea and Vomiting on Post-Chemotherapy Cervix Cancer
Patient in Prof. Dr. Margono Soekarjo Hospital Purwokerto. In 1st International
Conference on Community Health (ICCH 2019) (pp. 30-35). Atlantis Press.
20

21