This essay explores the critical health issue of Chronic Kidney Disease (CKD) affecting Aboriginal and Torres Strait Islander peoples in Australia. It highlights the disparity in health outcomes between indigenous and non-indigenous Australians, emphasizing the impact of social, cultural, and demographic factors on the prevalence of CKD. The essay identifies key contributors to CKD, such as diabetes, hypertension, and glomerulonephritis, while also addressing the role of socioeconomic conditions, limited access to healthcare, and cultural differences. Furthermore, it discusses effective healthcare strategies, including diabetes and blood pressure control, and stresses the importance of culturally sensitive healthcare practices. The essay concludes by advocating for comprehensive interventions that address both the medical and social determinants of health to improve the well-being of Aboriginal and Torres Strait Islander communities.