This case study focuses on the nursing care of George, a 51-year-old Aboriginal and Torres Strait Islander man diagnosed with stage 4 chronic kidney disease secondary to diabetic nephropathy. The assessment utilizes the Levitt-Jones clinical reasoning cycle to prioritize nursing interventions. The analysis identifies fluid retention and hypertension as key priority issues, with detailed discussions on their pathophysiology, assessment findings, goal setting, and nursing interventions. The study emphasizes evidence-based practice, cultural safety, and patient education, highlighting the importance of monitoring vital signs, fluid balance, medication adherence, and providing psychological support. The conclusion underscores the significance of critical thinking, research skills, and the application of the Levitt-Jones cycle in managing chronic kidney disease and preventing complications.