This report investigates the effectiveness of cognitive therapy alongside glycemic therapy for diabetic patients with depression, using a PICO framework to formulate the research question. It evaluates a study on motivational enhancement therapy plus cognitive behavior therapy, highlighting its positive impact on depressive symptoms and quality of life in type-2 diabetes patients. The report emphasizes the intricate relationship between diabetes and depression, advocating for integrated interventions that address both conditions. A literature review supports the benefits of cognitive behavioral therapy and mindfulness-based cognitive therapy in managing depressive symptoms and improving diabetes management. It also explores the potential of web-based and mobile interventions for patients with limited access to mental healthcare. The report recommends training healthcare professionals in cognitive behavioral therapy and developing innovative strategies to reach remote patients, ultimately improving the quality of life for individuals with comorbid diabetes and depression.