This report provides a comprehensive analysis of post-operative care for patients who have undergone colostomy surgery. It explores the various impacts of the surgery, including biopsychosocial, cultural, and social challenges, such as psychological effects like low self-esteem, depression, and anxiety, and the impact on mobility and social interaction. The report examines the patient's history, including chronic conditions like diabetes, heart failure, and gout, and their influence on post-operative care. It details essential nursing interventions, such as dietary management, wound evaluation, and stoma care, including strategies for preventing infections and allergic reactions. The report also covers medication management, including the use of analgesics to manage pain and proton pump inhibitors to reduce gastric acid secretion. Finally, it emphasizes the importance of providing clear instructions to caregivers to ensure effective long-term patient care and improved self-esteem.