This essay delves into the critical role of professional communication in nursing practice, emphasizing its impact on patient safety and the development of therapeutic nurse-patient relationships. The essay explores three key concepts: verbal and non-verbal communication skills, person-centred care, and effective documentation. It uses the case study of George Pham to illustrate the practical application of these concepts. The discussion highlights how effective communication, including sensitivity to cultural and linguistic diversity, fosters trust and enables nurses to accurately assess and diagnose patients, leading to the planning and implementation of appropriate interventions. Furthermore, the essay emphasizes how person-centred care empowers patients and promotes a holistic approach to care, while effective documentation ensures clear communication among healthcare professionals and supports the delivery of safe, quality care. The conclusion reinforces the essential nature of effective nurse-patient communication for achieving high-quality care and patient safety.