This essay presents a case study of George Williamson, a 72-year-old male diagnosed with COPD, who continues to smoke and exhibits nonadherence to his medication. The essay identifies two primary nursing problems: smoking and unfavorable behavior, including a sedentary lifestyle and medication noncompliance. It discusses the pathophysiology of COPD, linking it to assessment data such as SpO2, FEV1, and blood pressure. The essay explores both pharmacological and non-pharmacological interventions. Pharmacological interventions include Bupropion SR and Varenicline for smoking cessation, while Cognitive Behavioral Therapy (CBT) is proposed to address the smoking issue. For the unfavorable behavior, the essay suggests physiotherapy and patient education, emphasizing the importance of exercise, medication adherence, and developing a therapeutic relationship with the patient. The essay emphasizes the role of nurses in implementing and evaluating these interventions to improve George Williamson's health outcomes.