This essay provides a comprehensive overview of Coronary Artery Disease (CAD), beginning with an introduction to the disease, also known as ischemic heart disease. It describes the normal physiology of coronary arteries, which supply blood and oxygen to the cardiac muscles, and explains how disruptions in blood flow due to plaque buildup can lead to myocardial ischemia and heart attacks. The essay then delves into the pathophysiology of CAD, detailing the process of atherosclerosis, including plaque formation, and the role of inflammation in the development of the disease. It further explores the pharmacology of CAD, focusing on the use of beta blockers in managing chest pain and improving blood supply to the myocardium. The essay concludes with a summary of the key points and highlights the effectiveness of beta blockers in the pharmacological treatment of CAD. The essay also includes relevant references to support the information presented.