Research Draft on Coronary Artery Disease Treatment Effectiveness

This research draft examines the effectiveness of treatments for coronary artery disease (CAD), focusing on the comparison between coronary-stent placement and balloon angioplasty. The paper builds upon previous findings, highlighting the superiority of stent replacement therapy in reducing restenosis. The core of this report is an annotated bibliography that explores recent advancements, particularly the use of drug-eluting stents with thinner struts or biodegradable polymers to minimize clot formation and improve patient outcomes. Key sources include Mennuni et al. (2016), which discusses the impact of technological advancements in stents, and Vlachojannis et al. (2017), which compares biodegradable and durable polymer stents over a 5-year period. The research emphasizes the ongoing evolution of CAD treatment, with biodegradable polymer stents emerging as a promising approach to enhance safety and efficacy for patients.

Running head: RESEARCH DRAFT
RESEARCH DRAFT
Name of the Student
Name of the University
Author Note

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RESEARCH DRAFT
Abstract:
The purpose of the paper is to provide better treatment for patients with coronary heart
disease. The research is directed by the research question “Which treatment is more effective for
coronary artery disease between Coronary-stent placement and balloon angioplasty"? In the
previous paper, the major finding was stent replacement therapy is a better treatment than
balloon angiography since it reduces the prevalence of restenosis. In this paper, the major finding
of the annotated bibliography is that drug-eluting stent with thinner struts or biodegradable
polymer profile is excellent approach ion reducing clot or occlusion in patients.

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Outline and intended argument:
As discussed in the previous paper that coronary heart disease is one of the most
common causes of high morbidity rate around the globe. Approximately 15 million Americans
are currently living with coronary artery disease, a condition where build up plaques are
observed in the arteries (Byrne et al., 2013). The research question of the research is “Which
treatment is more effective for coronary artery disease between Coronary-stent placement and
balloon angioplasty"?
In the previous research, it was observed that in order to reduce the prevalence of
restenosis, stent replacement therapy is better treatment compared to the balloon angioplasty in
patients with coronary artery disease. However, the recent research suggested that stent
replacement using biodegradable polymer is a better approach to treat patients with coronary
heart disease. The paper will provide the direction to the search through two annotated
bibliography.
Mennuni, M. G., Pagnotta, P. A., & Stefanini, G. G. (2016). Coronary stents: the impact of
technological advances on clinical outcomes. Annals of biomedical engineering, 44(2), 488-
496.
The paper emphasized the impact of technological advancement such as coronary stents
in patients with coronary artery disease. The researchers conducted a narrative review of the
research to gain an understanding of technological advancement. The researchers suggested that
in early era balloon angioplasty was replaced by bare metals stents that help to avoid the abrupt
occlusion. After conducting detailed research it can be said that drug-eluting stent with thinner

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RESEARCH DRAFT
struts or biodegradable polymer profile is a novel approach to improve the clinical outcome since
it significantly reduces the occlusion.
Vlachojannis, G. J., Smits, P. C., Hofma, S. H., Togni, M., Vázquez, N., Valdés, M., ... &
van der Ent, M. (2017). Biodegradable polymer biolimus-eluting stents versus durable
polymer everolimus-eluting stents in patients with coronary artery disease: a final 5-year
report from the COMPARE II trial (abluminal biodegradable polymer biolimus-eluting
stent versus durable polymer everolimus-eluting stent). JACC: Cardiovascular
Interventions, 10(12), 1215-1221.
The paper focused on the investigation of 5 years outcome of the biodegradable
biopolymer biolimus eluting tent and durable everolimus-eluting stent in patients with coronate
heart disease. In order to gain the answer, the researchers conducted 1 to 3 years of randomized
control trial of patients. The result suggested that both biodegradable polymer stent replacement
are effective in providing safety and a faster recovery in a patient with coronary heart disease.
The rate of combined safety is 15%. Hence, the efficacy of treatment is required to evaluate
further.

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Reference:
Byrne, R. A., Neumann, F. J., Mehilli, J., Pinieck, S., Wolff, B., Tiroch, K., ... & Hausleiter, J.
(2013). Paclitaxel-eluting balloons, paclitaxel-eluting stents, and balloon angioplasty in
patients with restenosis after implantation of a drug-eluting stent (ISAR-DESIRE 3): a
randomised, open-label trial. The Lancet, 381(9865), 461-467.
Jain, R. K., Chakravarthi, P., Shetty, R., Ramchandra, P., Polavarapu, R. S., Wander, G. S., ... &
Jain, N. (2016). One-year outcomes of a BioMime™ Sirolimus-Eluting Coronary Stent
System with a biodegradable polymer in all-comers coronary artery disease patients: The
meriT-3 study. Indian heart journal, 68(5), 599-603.
Mennuni, M. G., Pagnotta, P. A., & Stefanini, G. G. (2016). Coronary stents: the impact of
technological advances on clinical outcomes. Annals of biomedical engineering, 44(2),
488-496.
Vlachojannis, G. J., Smits, P. C., Hofma, S. H., Togni, M., Vázquez, N., Valdés, M., ... & van
der Ent, M. (2017). Biodegradable polymer biolimus-eluting stents versus durable
polymer everolimus-eluting stents in patients with coronary artery disease: final 5-year
report from the COMPARE II trial (abluminal biodegradable polymer biolimus-eluting
stent versus durable polymer everolimus-eluting stent). JACC: Cardiovascular
Interventions, 10(12), 1215-1221.