Coumarin-Chalcone Hybrids: Synthesis and Anticancer Evaluation

This document provides detailed experimental procedures, spectral data, and analytical results for the synthesis and characterization of novel coumarin-chalcone hybrid derivatives. The research focuses on the synthesis of various coumarin-based compounds, including compounds 2-27, and their corresponding spectra. The study begins with the synthesis of key intermediates such as 4-Hydroxy-naphthalene-1,3-dicarbaldehyde and 5-sec-Butyl-4-hydroxy-benzene-1,3-dicarbaldehyde. These intermediates are then used to synthesize various coumarin derivatives (3-5, 18-20) and chalcone derivatives (6a-6c). Furthermore, the document outlines the synthesis of coumarin-chalcone hybrid derivatives (7-15), detailing their spectral characteristics (1H NMR, 13C NMR, IR, and ESI-MS) to confirm their structures. The information includes detailed synthetic procedures, analytical data, and spectral analysis, which helps in understanding the chemical properties and potential anticancer activity of these compounds. The research was conducted at the Central Drug Research Institute (CDRI-CSIR), Lucknow, India, and provides valuable insights into the development of potential anticancer agents. This document serves as supporting information for the research conducted.