This report, prepared for HLSC122, critically appraises the effectiveness of e-cigarettes for smoking cessation, using Joanne's case study as a focal point. It examines authorship, research questions, design, methods, and results of relevant studies, particularly focusing on the comparison between e-cigarettes and other nicotine replacement therapies. The analysis includes a discussion of e-cigarette use in clinical practice, highlighting its acceptance and potential benefits, while also addressing the barriers to implementation, such as limited data and resource constraints. The report concludes with a summary of the key findings, emphasizing the need for further research, especially concerning the health effects of nicotine-free and nicotine-containing e-cigarettes, to provide a comprehensive understanding of their impact on public health and smoking cessation strategies. The references used in the study are also listed to provide more in-depth information about the subject.