This report provides a critical review of current literature on evidence-based interventions for depression, focusing on both pharmacological and therapeutic approaches within the context of contemporary practice. The report begins with an introduction defining depression as a common mental illness impacting daily life and highlighting the importance of evidence-based treatments. It then presents a critical analysis of various research papers, examining the views of authors on topics such as the effectiveness of cognitive behavioral therapy, psychotherapy, and pharmacological interventions like antidepressants. The report also discusses the impact of these interventions on patients, including the use of contemporary therapies like ECT. Furthermore, it emphasizes the importance of recognizing the signs and symptoms of depression, evaluating the underlying reasons for depression, and adopting effective evidence-based interventions. The report concludes by highlighting the importance of recognizing and treating depression to improve patient outcomes and ensure best practice in a clinical setting. The report adheres to APA style referencing and includes a comprehensive list of references.