This report addresses the critical issue of delirium in acute hospital settings, a complex mental disability characterized by confused thinking and decreased awareness. It begins with a detailed search plan to identify relevant resources, followed by a comprehensive literature review using a structured search strategy, including databases, books, journals, and websites. The core of the report comprises an extraction/summary table for each paper, meticulously outlining the purpose, sample, design, methodology, key findings, and level of evidence. The report then synthesizes the research to provide recommendations for best practices in delirium prevention, focusing on the introduction of the problem, critical analysis of the research, summarization of key findings, and evidence-based interventions. The report examines the causes of delirium, including severe illness, metabolic changes, infection, surgery, medication, and substance withdrawal, and addresses the different categories of delirium: hyperactive, hypoactive, and mixed. The final section of the report provides recommendations for best practices to prevent delirium in acute hospital settings. The report emphasizes the need for nursing staff to detect delirium and apply early interventions to reduce adverse events. It highlights the importance of early engagement of multidisciplinary staff and interventions on delirium incidence.