This case study focuses on a 41-year-old female named Mary, presenting with symptoms of depression. The assignment begins with a Mental Status Examination (MSE) evaluating her appearance, attitude, mood, affect, speech, thought process, thought content, insight, impulsivity, and reliability. Part 1 includes a clinical formulation based on the 5Ps (Predisposing, Precipitating, Perpetuating, Protective, and Presentation) and a detailed nursing care plan addressing Mary's low self-confidence, feelings of worthlessness, and sleep difficulties. The nursing interventions emphasize counseling, family involvement, and establishing a regular sleep schedule. Part 2 delves into therapeutic engagement, highlighting the importance of a therapeutic relationship and cultural safety in providing care. It also discusses recovery-oriented nursing care principles, such as patient uniqueness, real choices, and partnership. The case study concludes with references and a clinical handover plan, emphasizing the family's role in Mary's recovery.