This report examines depression, a prevalent mental health disorder, focusing on its clinical manifestations and psychopathology. It explores the subjective and objective signs of depression, categorized by severity, and delves into the genetic, biological, social, and psychological causes. The report then discusses psychopharmacology, including the use of antidepressants like MAOIs, TCAs, and SSRIs, and emphasizes the importance of patient education regarding medication side effects and self-management. Finally, the report reviews various treatment options, such as cognitive-behavioral therapy (CBT), acceptance and commitment therapy (ACT), interpersonal psychotherapy (IPT), electroconvulsive therapy (ECT), and counselling, highlighting the significance of recovery planning and patient involvement in treatment decisions. The report concludes by emphasizing the need to address the diverse signs and symptoms of depression, considering the patient's emotional trauma, and providing effective, individualized treatment plans that acknowledge the patient's choices and preferences.