This report provides a detailed analysis of diabetes, focusing on the role of insulin, different types of diabetes (Type 1 and Type 2), and their clinical manifestations. The report discusses the function of insulin, the hormones involved in glucose regulation, and the impact of hyperglycemia. It covers various aspects, including the causes, symptoms, and diagnostic criteria such as HbA1c. Furthermore, it explores the factors contributing to diabetes, such as obesity, family history, and lifestyle choices. The report also highlights the clinical signs and symptoms, including polyuria, polydipsia, and polyphagia. The report also provides an overview of the management strategies and the implications of diabetes on immune and inflammatory responses.