This report provides a comprehensive analysis of the relationship between disease and culture, examining both historical and contemporary perspectives. It begins by comparing and contrasting various viral diseases, such as polio, smallpox, SARS, avian flu, and swine flu, highlighting their similarities, differences, and the challenges societies face in managing them. The report then delves into specific disease outbreaks, such as the Ebola virus outbreak, exploring the factors that led to human exposure, the measures taken to control its spread, and the role of international cooperation. Further, the report investigates how ancient civilizations, including the Greeks and Romans, responded to pandemics and diseases, describing their traditions and practices, and assessing their effectiveness. Finally, the report examines the case of leprosy in the United States, discussing the historical handling of the disease, the impact on affected individuals, and the current status of leprosy in the modern world, including treatment and prevention strategies. The report incorporates scholarly references and uses APA format for citations.