This nursing assignment investigates the effectiveness of fish oil in treating osteoarthritis, focusing on a 65-year-old woman, Peggy, experiencing knee pain. The report uses a PICO question to guide a search strategy employing keywords such as 'osteoarthritis,' 'fish oil,' and 'joint pain.' The search utilizes MEDLINE and CINAHL databases, yielding relevant articles on fish oil's efficacy and safety. The assignment reviews two studies: one assessing different dosages of fish oil and another comparing low and high doses, both indicating potential benefits for pain reduction and improved knee movement in osteoarthritis patients. The conclusion emphasizes the evidence-based practice, suggesting that fish oil may be a safe and effective treatment option for Peggy and others suffering from osteoarthritis, although further research is needed to confirm this.