Investigation of Ethyl Acetate Production, Testing, and Impurities

This report examines the identification and analysis of impurities in ethyl acetate (ethyl ethanoate). It begins by describing the Fischer Esterification process, the Tischenko reaction, and the alkylation of acids, providing context for the subsequent impurity analysis. The core of the report focuses on the techniques used to identify and quantify impurities. These include infrared spectroscopy, where the spectrum of ethyl acetate is compared to a standard to detect deviations; gas chromatography, which separates the components of a mixture, allowing for the identification of impurities such as acetic acid and ethanol; and Karl Fischer titration, which measures the water content in the sample. The report references relevant academic sources to support the methodologies and findings, offering a comprehensive overview of ethyl acetate quality control.

EXPLORE THE MANUFACTURING TECHNIQUES AND
TESTING METHODS FOR AN ORGANIC LIQUID

TABLE OF CONTENTS
Description ......................................................................................................................................1
Identification of impurities in ethyl acetate (ethyl ethanoate).........................................................1
REFERENCES................................................................................................................................2

Description
Fischer Esterification: This process is the treatment of an alcohol with carboxylic acid in the
presence of inorganic mineral acid catalyst (Furuta, Fukuyama and Ryu, 2017). The used
conditions involve using an acidic catalyst to initiate the nucleophilic attack and formation of
aqueous layer where it gets disposed off in the sink.
Tischenko: This is chemical reaction between aldehyde and alkoxide producing esters in
presence of catalysts. Conditions include redox reactions.
Avada (alkylation of acid): This takes place by adding photons to a carbonium ion with double
bonds. Herein
Identification of impurities in ethyl acetate (ethyl ethanoate)
IR: This is useful by using the differential infrared spectroscopy. Here the ethyl acetate would be
taken in the small china dish and placed in the machine where the spectrum is received on
periodical manner and the purity is measured in the form of stored spectrum which is digitally
subtracted from the sample.
Gas Chromatography: This contains stationary and a mobile phase where separation of complex
mixtures takes place (Nasrollahi and et.al., 2019). Here ethyl acetate is mixed with acetic acid
and ethanol in equal mixture and later plunger is put and the entire process occurs including
heating, centrifuging, concentrating, cooling and drying with sodium sulfate. For more
purification, chromatography column is inserted and receiving the IR spectrum.
Karl Fischer titration: This is the standardised titration procedure to measure the water amount
present in ethyl acetate. Herein the acidic titration will be conducted by adding iodine
mechanically with the sample using a KF reagent. The samples are dissolved in a solvent before
the beginning of titration.
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REFERENCES
Furuta, A., Fukuyama, T. and Ryu, I., 2017. Efficient flow fischer esterification of carboxylic
acids with alcohols using sulfonic acid-functionalized silica as supported
catalyst. Bulletin of the Chemical Society of Japan.90(5). pp.607-612.
Nasrollahi, S. and et.al., 2019. Gas chromatography-mass spectrometry analysis and
antimicrobial, antioxidant and anti-cancer activities of essential oils and extracts of
Stachys schtschegleevii plant as biological macromolecules. International journal of
biological macromolecules.
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