This presentation focuses on the implementation of evidence-based practice (EBP) and change theory within the context of HIV/AIDS care. It introduces the ACE Star Model of knowledge transformation, emphasizing its role in integrating research evidence into clinical settings to improve patient outcomes. The presentation outlines the model's five stages: discovery, evidence summary, translation, integration, and evaluation, illustrating how nurses can use these stages to translate research into effective interventions. It highlights the significance of EBP in HIV/AIDS, emphasizing the need for evidence-based nursing interventions and the potential for improved patient satisfaction and health outcomes. The presentation concludes by predicting that the application of the ACE Star Model will enhance nursing interventions, leading to better patient care and professional satisfaction.