This report discusses the application of change models and evidence-based interventions in clinical practice, focusing on Rogers' diffusion of innovation theory and various models like Stetler, ARCC, and Iowa. It emphasizes evidence-based practices (EBP) and their integration into clinical settings to improve patient care and reduce healthcare costs. The report also explores the Duck's Change Curve model for resisting infectious diseases like Carbapenem-resistant Enterobacteriaceae (CRE), detailing the five stages of denial, preparation, implementation, and outcome assessment for effective intervention and behavioral change in high-risk environments. The ultimate goal is to enhance clinical expertise, improve patient outcomes, and promote social change through statistical evidence-based clinical practice.