This essay examines the implementation of Evidence-Based Practice (EBP) within the context of the emergency department (ED), focusing on the challenges and barriers that hinder its effective application. The essay begins by defining EBP and emphasizing its importance in healthcare, highlighting its potential to improve patient outcomes and reduce costs. It then delves into the specific difficulties faced by ED staff in adopting EBP, such as overcrowding, heavy workloads, lack of time, and organizational limitations. Individual barriers, including lack of knowledge, skills, and confidence, are also explored. The essay then proposes strategies to overcome these obstacles, including changing organizational culture, providing ongoing education and training, and maintaining adequate staffing levels. The role of clinical leaders in fostering an EBP-supportive environment is also discussed. Part B of the assignment formulates a clinical question regarding the effectiveness of computerized provider order entry (CPOE) systems in preventing medication errors within the ED, and the essay includes a PICO table and article selection process to address the clinical question.