This report delves into the critical area of infection control within nursing, emphasizing the principles of Evidence-Based Practice (EBP). It begins by defining EBP and highlighting the crucial role nurses play in preventing hospital-acquired infections (HAIs). The report then analyzes two peer-reviewed journal articles, one qualitative and one quantitative, to compare and contrast research methodologies, theoretical perspectives, and philosophical underpinnings. It explores the interplay between theory, research, and practice, emphasizing the importance of research in shaping clinical decisions and the application of evidence in nursing practice. Furthermore, the report examines the Iowa Model of EBP and how it can be applied to implement practice changes related to infection control. Ethical considerations in research are also addressed, along with the author's personal insights on how research has advanced their nursing knowledge. The report concludes by reiterating the significance of EBP in improving patient outcomes and the ongoing need for nurses to base their practices on scientific evidence. The student utilized keywords and database searches to locate relevant articles. The report includes references to support the discussion.