This report focuses on Evidence-Based Practice (EBP) in healthcare, specifically addressing the treatment of Rheumatoid Arthritis. The report begins by defining EBP and its importance in improving patient outcomes, followed by an explanation of the PICO framework for formulating clinical questions. A specific clinical question is presented: the effectiveness of short-term, low-dose corticosteroids compared to NSAIDs in patients aged 45-60 with Rheumatoid Arthritis. The background of the study is provided, highlighting the side effects of NSAIDs. The report then outlines the PICO elements for the question. Finally, a research study by Zhang et al. (2019) is discussed, which suggests that corticosteroids can reduce pain and inflammation associated with Rheumatoid Arthritis by reducing pain response and minimizing inflammation and edema. References for the mentioned studies are also provided.