This report delves into the application of evidence-based nursing practice to address the clinical issue of pressure injuries, particularly among elderly patients. The report begins by outlining the significance of pressure injuries and the need for effective interventions. A PICO question is formulated to guide the evidence search, focusing on the use of air mattresses to reduce the occurrence of pressure injuries. The methodology includes a search of the PubMed database, employing specific keywords and inclusion/exclusion criteria to identify relevant research articles. The report synthesizes the findings from five selected studies, including systematic reviews, observational studies, and randomized controlled trials, to evaluate the effectiveness of air mattresses in preventing pressure injuries. The analysis highlights the benefits of air mattresses in reducing the risk of pressure injuries and provides recommendations for practice change, such as implementing air mattresses for high-risk elderly patients. The report emphasizes the importance of continuous evaluation and further research to optimize patient outcomes and improve nursing care.