PBH91001 Evidence Appraisal: Depression in Hepatitis C Patients

This report presents an appraisal of evidence concerning depression in patients with chronic hepatitis C, particularly focusing on the impact of pegylated interferon alpha (PEG-IFN-α) therapy. The analysis includes a review of studies examining the prevalence of depression, sex differences in depressive symptomatology during treatment, and the interdisciplinary nature of depression as a medical problem. Key findings highlight a higher prevalence of depression in female subjects undergoing antiviral treatment for hepatitis C. The report also touches upon the broader implications of depression in relation to other somatic and mental illnesses, such as cardiovascular diseases, cancer, and epilepsy, emphasizing the need for an interdisciplinary approach to understanding and managing depression. Desklib offers a wealth of resources, including similar past papers and solved assignments, to aid students in their studies.

S80 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S72–S113
FC22
Pilot Project: Sound pillow treatment
to improve sleep quality for patients
with depression or bipolar diagnosis
with sleeping problems
H.N. Lund∗, I.N. Pedersen
Aalborg Psychiatric Hospital, Klinik Syd, Aalborg, Denmark
∗ Corresponding author.
A well-known symptom for patients with depression and bipolar
diagnosis is poor quality of sleep.This has a major impact on the
quality of life for the individual. Most recently, an article in the
Cochrane Review, Music for insomnia in adults, concludes that music
may be effective for improving sleep quality in adults with insomnia
symptoms [1].
A Research Project at Aalborg University Hospital, Psychiatry, in
Denmark has been initiated involving psychiatrists and nurses
from an outpatient unit and researchers and music therapists from
the Music Therapy Research Clinic at the hospital in an innova-
tive collaboration. A pilot project is started, where patients with
depression are given a sound pillow with special designed playlists,
offering selected calm music for the patients to use at home for
a period of 30 days. The listening periods are registered by the
patients. Questionnaires are filled out before and after the listening
period. A short semi-structured interview is taking place four times
throughout the listening period and as a follow-up, when patients
come in for control.
The aim is to investigate, whether music listening is helpful to
improve sleep quality and quality of life, and to investigate if music
listening can limit or replace medication. Discussion of first results.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Reference
[1] Jespersen, Koenig, Jennum, Vuust. Cochrane Rev 2015, http://dx.
doi.org/10.1002/14651858.CD010459.pub2 [Wiley & Sons Ltd.].
http://dx.doi.org/10.1016/j.eurpsy.2016.01.026
FC23
Sex differences in depressive
symptomatology in patients with
chronic hepatitis C during pegylated
interferon alpha therapy: A 72-week
prospective study
Z. Pavlovic1,∗, M. Jasovic-Gasic2, D. Delic3, N. Maric1,
O. Vukovic4, S. Pejovic5
1 School of Medicine, University of Belgrade, Clinic for Psychiatry,
Clinical Centre of Serbia, Belgrade, Serbia
2 School of Medicine, University of Belgrade, School of Medicine,
University of Belgrade, Belgrade, Serbia
3 School of Medicine, University of Belgrade, Institute of Infectious
and Tropical Diseases, Belgrade, Serbia
4 School of Medicine, University of Belgrade, Institute of Mental
Health, Belgrade, Serbia
5 Clinic for Psychiatry, Clinical Centre of Serbia, Clinic for Psychiatry,
Clinical Centre of Serbia, Belgrade, Serbia
∗ Corresponding author.
Introduction Treatment with pegylated interferon alpha (PEG-
IFN-␣) is associated with depression more frequently in chronic
hepatitis C (CHC) patients than with other inflammatory diseases.
Objectives To prospectively asses sex differences in the preva-
lence of depression in CHC patients during the PEG-IFN-␣, as well
as in the CHC group with no therapy.
Methods Sample consisted of 103 subjects with CHC on the
PEG-IFN-␣ and 103 subjects with CHC without interferon ther-
apy. The diagnosis of depressive disorder was established by using
Structured Clinical Interview and Criteria of International Classifi-
cation Disorder. The severity of depression was assessed by using
Hamilton Depression Rating Scale (HAMD ≥ 8) prior to PEG-IFN-␣
(baseline) and at the follow-up visits (4th,12th, 24th, 48th, 72nd
week).
Results During the course of PEG-IFN-␣, 49.5% of subjects showed
depressive symptomatology (HAMD ≥ 8).Except at baseline and
in the 72nd week, on the all other follow-up visits the preva-
lence of depression was significantly higher in female subjects
(*all Ps < 0.05).The strongest difference was observed in the 12th
week: of all the subjects with HAMD ≥ 8,68.8% were female and
32.7% were male (P < 0.001).The multivariate logistic regression
model showed that female sex is a very strong predictor for the
development of depression during the interferon treatment [Exp
(B) = 6.729]. There were no significant sex differences in the preva-
lence of depression in the control group.
Conclusions Our study (the longest study in this area) indicate
that the prevalence of depression is significantly higher in female
subjects with CHC during antiviral treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.027
FC24
Depression as an interdisciplinary
problem
A. Vasileva1,∗, N. Neznanov (Director)2
1 Bekhterev Psychoneurological Institute, Medical Faculty of St.
Petersburg University, neurosis and psychotherapy, Saint-Petersburg,
Russia
2 Bekhterev Psychoneurological Institute, Medical Faculty of St.
Petersburg University, Saint-Petersburg, Russia
∗ Corresponding author.
Traditionally depression was defined as a mental illness. Acknowl-
edgment of biopsychosocial model in modern medicine brought
about a number of interdisciplinary studies. In the meantime, a
number of correlations in the onset, cause and prognosis between
depression and other somatic as well as mental illnesses were
discovered. The research results showed that from one hand,
depression could be an independent factor of the possible develop-
ment of heart infarct, on the other hand it can influence the recovery
process in cardiological patients. The conducted studies established
some common pathways in depression and vascular diseases devel-
opment. Psychoneuroimmunological research gives the data about
the influence of anxiety and depression on the interleukine pro-
file that could be a matter of further investigation of the possible
links between depression and cancer diseases. The other dimension
is the addiction impact on depression onset. The interrelationship
between epilepsy as organic brain disease and depression is also
worth of attentional. Hypercortisolemia and low-grade inflamma-
tion plays an important role both in depression and dementia.
There is also a strong correlation between personality traits and
depression itself and as response to unfavorable circumstances and
somatic illness as well. We propose to apply to depression the
principles of pathological stable circuits with the self-sustained
reverbation engram chains mechanisms.All these data calls for
consideration of depression as an interdisciplinary phenomena.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.028