This essay explores the evolution of nursing practice, starting with Florence Nightingale's contributions and tracing the development of nursing roles, education, and practices in the United States. It discusses the shift from informal care to structured nursing programs, the impact of events like the Civil War and World Wars, and the emergence of specialized and advanced practice nurses. The essay also examines the differences between Associate Degree in Nursing (ADN) and Bachelor of Science in Nursing (BSN) prepared nurses, highlighting the importance of evidence-based practice and interdisciplinary collaboration in modern healthcare settings. It concludes by emphasizing the need for supportive policies and the critical role of nursing organizations in advancing the profession to ensure safer and better patient outcomes.