Exercise Physiology 2: Article Review of Friedenreich et al. on Cancer

This report is an article review of Friedenreich et al.'s research on the application of precision medicine for cancer patients through exercise. The study examines the relationship between physical activity, cancer outcomes, and molecular approaches, highlighting the need for further research to objectively evaluate physical activity throughout the diagnosis process. The authors discuss precision medicine's goals, addressing patient variability in response to medical therapy, and the potential of targeted exercise prescriptions. The review also mentions other researchers identifying the effects of exercise and application of precision medicine, along with findings and recommendations that facilitated the research on the article. The article expands on molecular epidemiology studies and their role in guiding trials on precision exercise. While the authors provide valuable insights, the review notes the omission of other potential ways of reducing cancer outcome defects. The analysis emphasizes the importance of exercise in cancer treatment and survival, providing significant knowledge to the community.

RUNNING HEAD: EXERCISE PHYSIOLOGY 1
Exercise physiology
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EXERCISE PHYSIOLOGY 2
Article review
Researchers Friedenreich et al attempted to research in the application of precision
medicine for patients to exercise frequently as an advanced treatment dimension for individuals
with cancer. The authors of this article aimed to find this current dimension by assessing
epidemic literature that interrelates with post diagnosis of physical activities to cancer outcomes
and various genetics (Friedenreich et al 2016). Over the years, based on few studies several risks
of recurrence were also reduced. Consequently, Friedenreich et al identified some other studies
relating to exercises activities and cancer results of molecular approaches suggesting that in
order to enhance this evidence, future observations research is required to evaluate physical
activity objectively through the entire process of diagnosis. Clearly, this indicated that analyzed
trials with clinical cancer results give the crucial evidence relating exercises to cancer and
molecular approaches.
In the first section of this article, Friedenreich et al presented a new approach in oncology
whose purpose is to address variability in how a cancer patient responds differently to medical
therapy. It is clear that the authors put much contemplation in precision medicine recognizing
various factors that lead to this heterogeneity. The author provided a primary and secondary goal
of precision medicine. The primary goal involved providing an intervention to individuals who
will benefit while the secondary goal provides an oversight on avoiding the side effects and cost
incurred while providing the patients with the intervention (Friedenreich et al 2016). Similar
researchers have also identified and recognized how cancer patients respond differently to
exercise. However, they showed that there exists some variability in effects of exercise and
application of precision medicine.

EXERCISE PHYSIOLOGY 3
Furthermore, Friedenreich et al included several findings and recommendations that
facilitated the research on the article. The authors showed the rising need in most of the cancer
cases in physiologists identifies the precise cure as it is shown by the various groups recording
the genetic code. Some variations between exercise and medicine have effects on the use of
various treatments as seen in physiology (Jameson & Longo 2015). In most cases, physiological
aspects are always based on aerobic, strength, balance and flexibility. In this case, understanding
of cancer biology facilitates the development of targeted exercise prescriptions such as dosage
and timing in order to improve cancer outcomes.
In the final section of this article, Friedenreich et al expanded on other precision medicine
findings. The authors indicated that molecular epidemiology studies generate a different
hypothesis to guide trials on precision exercise. Epidemiologic research findings are significant
in assessing relationships between exercise activities and cancer survival for affected patients.
Additional large molecular studies have emerged continuously in the past five years (Meyerhardt
et al 2006). This evidence will incorporate preclinical testing, safety and efficacy trials on the
importance of physical activities for cancer treatment. While this meticulous analysis is largely
palatable, in the entire article the authors omit and do not mention on other possible ways of
reducing cancer outcome defects other than physical exercises. Whether this sloppy oversight is
unclear the author does not provide the response to such arguments. Nevertheless, Friedenreich
et al work provided the impetus for an understanding of oncology and precision medicine
enabling the entire community to acquire such significant knowledge with an aim to ensure
cancer survival in patients.

EXERCISE PHYSIOLOGY 4
References
Friedenreich, C. M., Neilson, H. K., Farris, M. S., & Courneya, K. S. (2016). Physical activity
and cancer outcomes: a precision medicine approach.
Jameson, J. L., & Longo, D. L. (2015). Precision medicine—personalized, problematic, and
promising. Obstetrical & Gynecological Survey, 70(10), 612-614.
Meyerhardt, J. A., Giovannucci, E. L., Holmes, M. D., Chan, A. T., Chan, J. A., Colditz, G. A.,
& Fuchs, C. S. (2006). Physical activity and survival after colorectal cancer diagnosis.
Journal of clinical oncology, 24(22), 3527-3534.
Wasserman, K., Hansen, J. E., & Sue, D. Y. (2011). Principles of exercise testing and
interpretation: including pathophysiology and clinical applications. Wolters Kluwer
Health.