This report assesses the efficacy of exercise as a treatment for adolescent depression, addressing the rising rates of depression and suicide among adolescents and the limitations of pharmacological treatments. It explores studies on exercise interventions, highlighting their potential to reduce depression levels. The review follows a structured approach, including formulating a PICOT question, conducting literature searches, critically appraising evidence, integrating evidence with clinical expertise and patient preferences, evaluating outcomes, and outlining project outcomes and dissemination strategies. The findings suggest that structured exercise can be a beneficial non-pharmacological approach to managing adolescent depression, supported by both randomized controlled trials and quasi-experimental studies. The report emphasizes the importance of involving trained physical exercise professionals and disseminating these findings to healthcare professionals to promote the adoption of exercise as a treatment option.