This essay delves into the multifaceted factors that contribute to ill health, encompassing psychobiological, social, and individual determinants. It begins by exploring psychobiological factors, highlighting the impact of stress and biological changes, such as hormonal shifts during pregnancy, on health conditions like asthma and diabetes. The essay then examines social factors, including the influence of education, socioeconomic status, neighborhood conditions, and exposure to crime and violence. It emphasizes how these factors can affect both mental and physical health. Finally, the essay addresses individual differences, such as behavioral activities like substance use, dietary habits, and screen time, and their implications for health. The integration of these perspectives underscores the interconnectedness of biological, psychological, and social influences on overall health and well-being.