Molecular Biology Concept: Brain Regeneration and Gene Expression

This report delves into the molecular biology concept of brain regeneration, drawing insights from the movie 'Alita'. It explains endogenous regeneration, where the brain's cells repair and regenerate, particularly in the subventricular area. The report highlights how damaged brain cells can be replaced through the activation of endogenous stem cells and pro-regenerative molecules. It discusses the role of epigenetics and neural stem cell differentiation, alongside transcription factors, in inducing gene expression and facilitating brain function restoration. The report emphasizes that brain damage does not necessarily mean the end of brain function, as the brain has mechanisms to initiate regeneration. The report includes references to support the concepts discussed, providing a detailed understanding of the molecular processes involved in brain repair and regeneration.

Running head: MOLECULAR BIOLLOGY CONCEPT 1
Molecular biology concept
Student’s Name
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MOLECULAR BIOLLOGY CONCEPT 2
I would like to present the concept in the movie regarding molecular cell biology
concept. First and foremost, it is important to understand what endogenous regeneration mean.
According to Kinsella et al. (2019), it is the process that occurs in the brain because of the ability
of the cells in the brain to engage in the repair and the general regeneration process.
The process occurred in the brain’s sub ventricular area, where the cells of the nerve
could effectively differentiate themselves into neurons of adult population. The damaged brain
induced endogenous stem cells and numerous pro-regenerative molecules to participate in
replacement and replacement of the damaged brain cells from Alita (Wells & Watt, 2018). As a
result, it led to differentiation of various brain cells within the brain. They all wholesomely
joined to differentiate through epigenetics and the injection of neural stem cells that had been
previously cultured within the brain itself. This happened alongside transcription factors and
other associated chemicals that ultimately induced the expression of the gene in the damaged
Alita’s brain and enabled the maintenance of the function. Transcription factors acts as regulators
of gene expression which links stimuli to neuronal level’s long-term modifications.
It is thus evident that brain damage does not mean the end of brain functioning. Alita’s
damaged brain would have been viewed as the end of her brain functioning. On the contrary, the
brain has its own way of inducing the stem cells to facilitate the regeneration process. It is
through the regeneration that the genes can be expressed again and finally repair the brain and
enable the routine functions of the brain.

MOLECULAR BIOLLOGY CONCEPT 3
References
Kinsella, S., Cooper, K., deRoos, P., Iovino, L., Jain, R., & Dudakov, J. A. (2019). NOD2
regulates distinct pathways of endogenous thymic regeneration after injury.
Wells, J. M., & Watt, F. M. (2018). Diverse mechanisms for endogenous regeneration and repair
in mammalian organs. Nature, 557(7705), 322-328.

MOLECULAR BIOLLOGY CONCEPT 4