Analysis of Family Pedigree: Disease Patterns and Genetic Risks

This assignment delves into the analysis of a family pedigree, focusing on the patterns of disease and potential genetic risks. The study examines the inheritance of conditions such as cancer, diabetes, obesity, and hypertension, considering the role of both genetic predispositions and environmental factors. The assignment highlights the significance of family history in assessing the likelihood of developing these diseases and the importance of genetic testing to confirm the presence of faulty genes. The interpretation of results includes identifying the risk factors based on the family's health history and the implications of these findings. The assignment emphasizes the need for client education regarding genetic and genomic services, providing relevant references to support the analysis.

FAMILY PEDIGREE
Condition
1:
diabetes
Condition
2: Obesity
Condition
3: Cancer
Condition
4:
Hypertensi
on
Anthony
Jr
Brothe
r
Fathe
r
UncleAun
t
Mother Aun
t Aun
t
Uncle
Grandp
a
Grandp
aGrandm
a
Grandm
a

GE N E T I C A SS E SS M E N T
• Genetic testing identifies that chromosomes and the genes or
proteins present of them that help to rule out or confirm a
doubt regarding genetic conditions that have been transmitted
from one generation to another. Molecular genetic tests are
performed to evaluate single genes to identify any mutation
from the accepted form. Chromosomal tests are performed to
evaluate if there is any variation in the chromosomal set that
involves large genetic changes (Ncbi, 2017).

PATTERNS OF DISEASE
• Cancer- Even though cancer is not genetically transmitted disease, however,
one is more likely to have cancer if they have inherited faulty genes from their
parents. They make a person more susceptible to the disease and about 3-10
people in every 100 cancer patient have inherited faulty genes. However, the
strength and likelihood of a faulty gene is present in the family are dependent
on the age of a person when they were diagnosed and if a specific type of
cancer to 2 close relatives on the same side of the family (Cancer research uk,
2015).
• Type 2 diabetes -There is no clear inheritance pattern of type 2 diabetes.
However, the risk increases with more people having diabetes on the same side
of the family.
• Obesity- Obesity is related to genetics, but a person with genes is only likely to
develop the condition under certain conditions like diet, lifestyle and other
genetic makeup.
• Hypertension- Elevated risk of hypertension is present when both parents
have the condition. The inheritance pattern is yet to be known.

THE INTERPRETATION OF
RESULTS
• The risk of having a faulty risk in the family is possible
when two people on the same side of the family have
similar types of cancer and have been diagnosed before
the age of 50. The second and third generation is free from
cancer except for one person. However, cancer occurs to 1
in 2 people in Europe after the age of 50.
• Diabetes runs on the mother's side of the family and two
closely related people have it, so the likelihood is high.
• The risk of obesity caused by genetic makeup is negligible.
• The risk of hypertension caused by genetic makeup is
negligible.

• The client has a likelihood to
develop diabetes and cancer as
it is present in two or more than
two closely related members of
the family.
• There might be chances of
cancer as it may skip a
generation or may not be
represented in a person even if
they had the gene.
• Genetic service can be used to
confirm the presence of a faulty
gene.
C L I E N T E D U C AT I O N
P E RT I N E N T T O T H E D ATA
F I N D I N G S
POSSIBLE INDICATIONS FOR
GENETIC AND GENOMIC SERVICES

REFERENCES
• Cancerresearchuk, (2015), Family history and inherited cancer
genes, Retrieved from
https://www.cancerresearchuk.org/about-cancer/causes-of-
cancer/inherited-cancer-genes-and-increased-cancer-risk/
family-history-and-inherited-cancer-genes
• Ncbi, (2017), Genetic Testing and Assessment, Retrieved from
https://www.ncbi.nlm.nih.gov/books/NBK236037/