This report is a literature review that explores the application of functional genomics in cancer research. It begins with an overview of functional genomics, explaining its role in studying gene structure, function, and control, and its use in comparing genotype and phenotype at the genomic level. The review then examines how functional genomics aids in cancer biology screening, highlighting the use of various technologies and the identification of molecular features to improve cancer diagnosis and treatment. The report discusses the evolution of cancer diagnosis, from early methods based on histology to the integration of genetic information, and the role of genomics in understanding genetic abnormalities. It emphasizes the importance of data integration, the application of deep sequencing technology, and the concept of personalized medical analysis. The review also addresses the limitations of functional genomics, such as the inadequate understanding of pharmacological genetic illnesses, and the importance of precision, accuracy, and oversight in clinical trials. The report concludes by emphasizing the significant impact of functional genomics in cancer screening, while acknowledging the challenges in data analysis.