NSC2500 Assignment 1: Lay Article Detailing Gout Pathophysiology

This assignment is a lay article designed for peers in the neurology department, discussing gout, a condition characterized by high uric acid levels. The article explains the pathophysiology of gout, focusing on the accumulation of monosodium urate (MSU) crystals in the joints, which triggers inflammation through the interaction of MSU with nearby cells. This process leads to the release of inflammatory mediators such as TNF-a, COX-2, IL-6, and IL-1. The article recommends the use of corticosteroids, like Medrol, to inhibit these inflammatory pathways. The author highlights that gout affects people of all ages and that the accumulation of MSU in the joints is the primary cause. The use of Medrol is suggested as a treatment option for this condition. This assignment provides an overview of the disease and how it can be treated.

Running head: SUBJECT- NSC2500 STUDENT ID- U1112475
Subject- NSC2500
Student ID- U1112475
Name of the University
Author Note

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SUBJECT- NSC2500 STUDENT ID- U1112475
Abstract
Introduction
The issues of gout are more common among the males than that of the female populat
the country and approximately 9 out of 10 people having gout in Australia is male. Gou
also be named as hyperuricemia. This condition mainly takes place due to the p
high amount of uric acid in the human body.
This article is mainly designed for the peers of the neurology department of thi
setting.
Discussion
In the human body the production of uric acid takes place due to the breakdown of puri
present in the food particles and human body as well. The produced uric acid is dissolv
the blood and passes into the urine through the kidneys. However, in some specific cas
body produces high amount of uric acids or the kidney may fail to excrete the
properly. Thus the high amount of urate crystals starts to accumulate in the body and t
also named as monosodium urate (MSU). The interaction of this MSU and nearb
stimulates the neutrophil entrance and formation of inflammatory macrophage ph
(M1). Therefore, this process leads to expression of various inflammatory mediators suc
TNF-a, COX-2, IL-6 and IL-1, and the CXCR2-binding chemokine CXCL1 and CXCL8. For
managing the disease condition, the inhibition of these inflammatory cytokines’ pathwa
using corticosteroids can be recommended. For this purpose, Medrol drug can be used
works in same mechanism and promotes the production of anti-inflammatory cytokines
Conclusion

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SUBJECT- NSC2500 STUDENT ID- U1112475
Hence, it can be stated that this disease can affect the people of any age groups and th
reason is associated with the accumulation of MSU in the joints. For treating the conditi
Medrol like drug (Group of corticosteroid) can be used.