This report provides a comprehensive analysis of the business environment impacting GlaxoSmithKline (GSK) and AstraZeneca (AZ). It identifies the purposes of various organizations, assesses stakeholder objectives, and examines the responsibilities of GSK towards its stakeholders. The report also evaluates the impact of UK government fiscal and monetary policies, competition and regulatory policies, and the forces of demand and supply on GSK and AZ. Furthermore, it analyzes the influence of the PESTEL framework, cultural environment, international trade, global factors, and EU policies on these multinational companies. The report also discusses different economic systems and market structures, providing a thorough understanding of the business landscape in which GSK and AZ operate.