This nursing research report investigates the critical link between hand hygiene compliance and the prevention of nosocomial infections within healthcare settings. The report begins by outlining the significance of the issue and establishes a PICOT question to guide the research. It then critically analyzes both quantitative and qualitative studies, exploring various methodologies and their respective results. The report examines the ethical considerations of the studies and their implications for nursing practice. The core focus is on evaluating evidence-based practices to improve hand hygiene adherence, thereby reducing hospital-acquired infections. The report proposes specific practice changes, emphasizing training and education to enhance healthcare professionals' compliance with hand hygiene guidelines. The conclusion reiterates the importance of addressing barriers to hand hygiene and highlights the role of evidence-based strategies in improving patient outcomes.