This report examines the critical importance of hand hygiene in healthcare settings, emphasizing its role in infection control and patient safety. It explores strategies such as the implementation of a no-touch policy using aseptic gloves, aligning with the STEEEP framework (safe, timely, effective, efficient, equitable, and patient-centered) and quality improvement (QI) principles like PDSA (Plan-Do-Study-Act) and Lean Six Sigma. The report highlights the significance of adhering to World Health Organization (WHO) guidelines for hand hygiene, including the use of alcohol-based hand rubs, antimicrobial soap, and other antiseptic agents. It discusses the application of DMAIC (Define, Measure, Analyze, Improve, Control) within the Lean Six Sigma framework to assess and enhance hand hygiene practices. The report concludes by advocating for the implementation of hand hygiene protocols to reduce infection risks and improve the overall quality of care, with a focus on the impact of sepsis in healthcare settings. The discussed strategies, including no-touch policies and proper handwashing, are crucial for improving patient safety and health outcomes.