Diabetes Report: HbA1c Test, Significance, and Analysis of Findings

This report provides a comprehensive overview of the HbA1c test and its significance in the context of diabetes. It explores the role of the HbA1c test as a crucial biomarker for assessing glycemic control and its impact on the diagnosis and prognosis of diabetes, including type 1, type 2, and gestational diabetes. The report highlights the pathophysiology of diabetes, the mechanism of HbA1c formation, and its advantages in providing reliable data and assessing long-term risks. The analysis covers the role of HbA1c in monitoring blood sugar levels and aiding in diagnosis, supported by references to relevant research and studies. The report emphasizes the importance of the HbA1c test in diabetes management, offering valuable insights into patient outcomes and treatment strategies.

Advanced Pathophysiology for Health Professionals
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Diabetes is a global and endemic ailment that affects a significant proportion of the
population. It has a rapid and increasing prevalence in both the developing and developed
countries. This rapid increase in prevalence and incidence requires that an appropriate initiative
to manage it is identified. There are three types of diabetes already identified, that is: type one
diabetes, type two diabetes and gestational diabetes. The mechanism of occurrence of diabetes
has been identified. In presence of beta cell dysfunction and insulin resistance, type one and type
two diabetes results. Gestational diabetes is manifested during pregnancy when the normal
feedback loop is affected by maternal and fetal needs (Kahn, 2014).
HbA1c tests is a highly crucial indicator of glycemic control and history for the last two
to three months of the affected individuals. The use of HbA1c as a relevant biomarker for
diagnosis diabetes was proposed by Keening in the year 1976. Proteins in the body are undergo
the process of glycation during various types of enzymatic reactions. Conversely, in the position
of hemoglobin, the process of glycation occurs without enzymatic reaction whereby the beta
chain and the n terminals of glucose form the Schiff base. Cumulatively, during the process of
rearrangement the Schiff base is cumulatively converted into the Amdori products of which the
best known is HbA1c. As the palsma level ofHbA1 rises so does that of blood sugar. Hence
HbA1 is a highly effective marker of blood sugar levels (Sherwani, 2016).
HbA1c provides advantages in two-folds that is it provides a highly reliable source of
data for the patient and its association with the cumulative risk associated with long-term
diabetes conditions of various kinds. The amount of information that is obtained from the HbA1c
test not only provides a clear picture of the prognosis of the patient but also aids in appropriate
diagnosis (Sherwani, 2016).

References
Kahn, S. E. (2014). Pathophysiology and treatment of type 2 diabetes: perspectives on the past,
present, and future. The Lancet, 383(9922), 1068-1083.
Sherwani, S. I. (2016). . Significance of HbA1c test in diagnosis and prognosis of diabetic
patients. . Biomarker insights, 11, BMI-S38440.