This essay provides a comparative analysis of health risks and susceptible populations in India and Senegal. It begins by identifying prevalent diseases in both countries, such as tuberculosis, respiratory diseases, malaria, and cardiovascular diseases, and discusses various risk factors including behavioral, physiological, demographic, environmental, and genetic factors. The essay then delves into specific outbreaks and crises, mentioning the high incidence of tuberculosis in India and the Chikungunya outbreak in Senegal, along with population mortality rates and the overall burden of disease. The discussion includes statistical data on mortality due to diseases like COPD and the impact of these health issues on vulnerable populations such as women, children, and tribal communities. The conclusion emphasizes the influence of risk factors on mortality rates and the susceptibility of populations in both countries, highlighting the need for targeted interventions to address these public health challenges.