This assignment presents a student's application of the ACE Star Model of Knowledge Transformation to address the issue of Health-Associated Infections (HAIs) in a medical-surgical nursing context. The assignment follows the framework of the ACE Star Model, starting with identifying the practice issue and the rationale behind it, which involves a rise in HAIs due to non-adherence to policies or procedural errors. The student formulates a PICOT question to guide the intervention, focusing on infection control programs. The assignment includes the selection of a systematic review from the Cochrane Database and other scholarly sources to support the evidence-based solutions, such as staff education and antimicrobial catheters. It outlines an action plan with stakeholders' roles and responsibilities, the nursing role in the change process, and the cost analysis required. The implementation plan involves gaining permission, educating staff, and establishing a timeline. The assignment also details measurable outcomes, data collection methods, and the use of pilot implementations. Finally, it describes the evaluation process, reporting outcomes, and the potential next steps for using the change process information. This assignment is a comprehensive analysis of the EBP change process in healthcare.